2-Methoxyestradiol

目录号: A10012

Apoptotic, antiproliferative and antiangiogenic agent

2-Methoxyestradiol

2-Methoxyestradiol Chemical Structure

CAS NO. 362-07-2

2-Methoxyestradiol是一种凋亡,抗增殖和抗血管生成剂。通过两种途径诱导p53诱导的细胞凋亡:p38和NF-κB的激活;和激活JNK和AP-1导致Bcl-2磷酸化。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 1,000.00
100 mg
¥ 1,700.00
200 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 710.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

2-Methoxyestradiol是一种凋亡,抗增殖和抗血管生成剂。通过两种途径诱导p53诱导的细胞凋亡:p38和NF-κB的激活;和激活JNK和AP-1导致Bcl-2磷酸化。
靶点信息
HIF-2α (Rat aortic smooth muscle A-10 cells) Microtubule Associated (Cell-free assay) HIF-1α (MDA-MB-231 cells)
In vitro (25°C) DMSO 55 mg/mL (181.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2%DMSO+30%PEG300+5%Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.07 mL 165.34 mL 330.69 mL
0.5 mM 6.61 mL 33.07 mL 66.14 mL
1 mM 3.31 mL 16.53 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10012
M. Wt 302.4
Formula C19H26O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 362-07-2
Synonyms 2-ME2
SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(OC)=C3

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