A-1155463

目录号: A16112

BCL-XL 抑制剂

A-1155463

A-1155463 Chemical Structure

CAS NO. 1235034-55-5

A-1155463是一种高效且选择性强的BCL-XL抑制剂,A-1155463显示与BCL-XL的皮摩尔结合亲和力(Ki = <0.01 nM),与BCL-2的结合力弱1000倍以上(Ki = 80 nM) 和相关蛋白BCL-W(Ki = 19 nM)和MCL-1(Ki> 440 nM)。

库存: 现货

规格 价格 数量
5 mg
¥ 1,200.00
10 mg
¥ 2,000.00
50 mg
¥ 8,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

A-1155463是一种高效且选择性强的BCL-XL抑制剂,A-1155463显示与BCL-XL的皮摩尔结合亲和力(Ki = <0.01 nM),与BCL-2的结合力弱1000倍以上(Ki = 80 nM) 和相关蛋白BCL-W(Ki = 19 nM)和MCL-1(Ki> 440 nM)。
靶点信息
BCL-XL Bcl-w Bcl-2 Mcl-1
440 nM(Ki)
In vitro (25°C) DMSO 78 mg/mL (116.45 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.93 mL 74.65 mL 149.3 mL
0.5 mM 2.99 mL 14.93 mL 29.86 mL
1 mM 1.49 mL 7.47 mL 14.93 mL
5 mM 0.3 mL 1.49 mL 2.99 mL

*The above data is based on the productmolecular weight 669.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A16112
作用机制 Inhibitor (抑制剂)
M. Wt 669.79
Formula C35H32FN5O4S2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1235034-55-5
Synonyms A 1155463, A1155463
SMILES O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O

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