ABT-737

目录号: A10255

Bcl-2 抑制剂

ABT-737

ABT-737 Chemical Structure

CAS NO. 852808-04-9

ABT-737是一种类BH3抑制剂,能同时抑制Bcl-xL,Bcl-2和Bcl-w,EC50分别为78.7 nM,30.3 nM和197.8 nM;但对Mcl-1,Bcl-B及Bfl-1没有抑制作用。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 900.00
50 mg
¥ 3,000.00
100 mg
¥ 4,800.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

ABT-737是一种类BH3抑制剂,能同时抑制Bcl-xL,Bcl-2和Bcl-w,EC50分别为78.7 nM,30.3 nM和197.8 nM;但对Mcl-1,Bcl-B及Bfl-1没有抑制作用。
Targets
Target Value
Bcl-2EC50:30.3nM
Bcl-xLEC50:78.7nM
Bcl-wEC50:197.8nM
Bcl-BEC50:1.82 uM
Bfl-1EC50>10 uM
Mcl-1EC50>10 uM
In vitro (25°C) DMSO 92 mg/mL (113.1 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2%DMSO+40%PEG300+5%Tween80+53%ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.29 mL 61.47 mL 122.94 mL
0.5 mM 2.46 mL 12.29 mL 24.59 mL
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL

*The above data is based on the productmolecular weight 813.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10255
作用机制 Inhibitor (抑制剂)
M. Wt 813.4
Formula C42H45ClN6O5S2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 852808-04-9
SMILES CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

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