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Acolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂，LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合，阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂（SERM）的一种。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.86 mL | 109.28 mL | 218.55 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.71 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12771 |
|---|---|
| 作用机制 | Modulator (调节剂) |
| M. Wt | 457.56 |
| Formula | C29H31NO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 182167-02-8 |
| Synonyms | EM652, EM-652, SCH-57068, SCH 57068 |
| SMILES | CC1=C([C@@H](OC2=C1C=CC(=C2)O)C3=CC=C(C=C3)OCCN4CCCCC4)C5=CC=C(C=C5)O |
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