Afuresertib HCl

目录号: A13030

AKT 抑制剂?

Afuresertib HCl

Afuresertib HCl Chemical Structure

CAS NO. 1047645-82-8

Afuresertib HCl,也称为GSK2110183,是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt(蛋白激酶B)的生物利用抑制剂。它结合并抑制Akt的活性,这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关,PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。

库存: 现货

规格 价格 数量
5 mg
¥ 750.00
10 mg
¥ 1,000.00
25 mg
¥ 1,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Afuresertib HCl,也称为GSK2110183,是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt(蛋白激酶B)的生物利用抑制剂。它结合并抑制Akt的活性,这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关,PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.56 mL 107.81 mL 215.62 mL
0.5 mM 4.31 mL 21.56 mL 43.12 mL
1 mM 2.16 mL 10.78 mL 21.56 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13030
作用机制 Inhibitor (抑制剂)
M. Wt 463.78
Formula C18H18Cl3FN4OS
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1047645-82-8
Synonyms GSK2110183, GSK 2110183
SMILES CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl

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