Alvelestat

Name: Alvelestat
SKU: A12779

目录号: A12779

neutrophil elastase 抑制剂

Alvelestat Chemical Structure

CAS NO. 848141-11-7

Avelestat，也称为AZD9668，是可口服的,高度选择性neutrophil elastase (NE)抑制剂，IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。

库存：现货

规格	价格	数量
5 mg	￥ 650.00
10 mg	￥ 900.00
25 mg	￥ 1,800.00
10mM * 1mL in DMSO	￥ 1,000.00

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生物活性

Avelestat，也称为AZD9668，是可口服的,高度选择性neutrophil elastase (NE)抑制剂，IC50和Ki分别为12 nM和9.4 nM,其选择性超过其他丝氨酸蛋白酶至少600倍。

靶点信息

neutrophil elastase	neutrophil elastase
9.4 nM(Ki)	12 nM

溶解度 *

In vitro	DMSO	87 mg/mL (159.47 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.33 mL	91.66 mL	183.32 mL
0.5 mM	3.67 mL	18.33 mL	36.66 mL
1 mM	1.83 mL	9.17 mL	18.33 mL
5 mM	0.37 mL	1.83 mL	3.67 mL

*The above data is based on the productmolecular weight 545.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12779
作用机制	Inhibitor (抑制剂)
M. Wt	545.5
Formula	C25H22F3N5O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	848141-11-7
Synonyms	AZD9668,AZD 9668,AZD-9668
SMILES	CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C