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AMG-47a是口服有效的Lck和T细胞增殖抑制剂。它在抗CD3诱导的小鼠IL-2产生中表现出抗炎活性（ED50 11 mg/kg）。
| In vitro | DMSO | 2 mg/mL (3.73 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.67 mL | 93.36 mL | 186.72 mL |
| 0.5 mM | 3.73 mL | 18.67 mL | 37.34 mL |
| 1 mM | 1.87 mL | 9.34 mL | 18.67 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.73 mL |
*The above data is based on the productmolecular weight 535.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13167 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 535.56 |
| Formula | C29H28F3N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 882663-88-9 |
| Synonyms | AMG47a, Geneticin |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CC4=CN=C(N=C4C=C3)NCCN5CCOCC5 |
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