产品详情

生物活性

AMI-1是一种有效的特异组蛋白甲基转移酶（HMT）抑制剂，对酵母Hmt1p和人PRMT1的IC50分别为3.0 uM和8.8 uM。

靶点信息

yeast Hmt1p	human PRMT1
3.0 μM	8.8 μM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 89 mg/mL (162.27 mM)
	Water	9 mg/mL (16.41 mM)
	Ethanol	Insoluble
In vivo	PBS	20 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.23 mL	91.17 mL	182.33 mL
0.5 mM	3.65 mL	18.23 mL	36.47 mL
1 mM	1.82 mL	9.12 mL	18.23 mL
5 mM	0.36 mL	1.82 mL	3.65 mL

*The above data is based on the productmolecular weight 548.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15916
作用机制	Inhibitor (抑制剂)
M. Wt	548.45
Formula	C21H14N2Na2O9S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	20324-87-2
Synonyms	AMI 1, AMI1, AMI-1 disodium salt
SMILES	O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]