AMPK

Catalog No.Inhibitor Name AMPK
A13720Dorsomorphin 2HCl
**
A14312WZ4003
****
A11970Dorsomorphin
**
A16281HTH-01-015
***
A11071A 769662
*
A15815ETC-1002

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

15 个项目

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  1. Phenformin hydrochloride

    Catalog No. A10717
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    Phenformin hydrochloride是双胍类药物中苯乙双胍的盐酸盐,具有抗糖尿病活性。 了解更多
  2. WZ4003

    Catalog No. A14312
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    NUAK kinase 抑制剂
    WZ4003是一种高度特异性的NUAK激酶抑制剂,对于NUAK1和NUAK2的IC50为20 nM和100 nM。 了解更多
  3. HTH-01-015

    Catalog No. A16281
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    NUAK1 抑制剂
    HTH-01-015是NUAK1的有效和选择性抑制剂(IC50 = 100 nM),并且不影响包括其他AMPK家族成员在内的139种其他激酶的活性。 了解更多
  4. PF-06409577

    Catalog No. A16801
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    AMPK 激活剂
    PF-06409577是口服生物可利用的AMPK激活剂,在TR-FRET试验中,对AMPK α1β1γ1的EC50为7 nM。在膜片钳试验(100 uM)中没有检测到对hERG的抑制作用,也不是人类主要细胞色素P450亚型微粒体活性的抑制剂(IC50>100 uM)。 了解更多
  5. MK-3903

    Catalog No. A17063
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    AMPK 激活剂
    MK-3903是有效的选择性AMPK激活剂(EC50 = 8 nM)。口服给药后,MK-3903在小鼠肝脏中表现出强大的靶标参与性,从而改善了小鼠的脂质代谢和胰岛素敏感性。 了解更多
  6. A-769662

    Catalog No. A11071
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    AMPK 激活剂
    A-769662是AMP激活的蛋白激酶(AMPK)的新激活剂。 了解更多
  7. Acadesine (Aicar,NSC 105823)

    Catalog No. A10028
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    AMPK 激活剂
    Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。 了解更多
  8. BML-275 (Dorsomorphin)

    Catalog No. A11970
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    AMPK 抑制剂
    BML-275 (Dorsomorphin)是一种可渗透细胞的吡唑并嘧啶化合物,显示为AMP激活的蛋白激酶(AMPK)和脂肪酸合酶抑制剂。 了解更多
  9. Dorsomorphin 2HCl

    Catalog No. A13720
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    BMP 抑制剂
    Dorsomorphin 2HCl (BML-275)是BMP信号传导的选择性小分子抑制剂,可促进胚胎干细胞的心肌发生。Dorsomorphin通过抑制骨形态发生蛋白信号转导逆转乳腺癌起始细胞的间质表型。 了解更多
  10. ETC-1002

    Catalog No. A15815
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    ACL 抑制剂 and AMPK 激活剂
    ETC-1002是一种新颖的,一流的可以降低LDL-C的小分子;肝AMP激活的蛋白激酶(AMPK)的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性(IC50 = 29 uM)。 了解更多
  11. GSK621

    Catalog No. A15896
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    AMPK 激活剂
    GSK621是有效的选择性AMPK激动剂。 了解更多
  12. YLF-466D

    Catalog No. A16284
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    AMPK 激活剂
    YLF-466D是一种变构AMPK激活剂。 了解更多
  13. ex229 (compound 991)

    Catalog No. A16795
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    AMPK 激活剂
    ex229 (compound 991)是一种有效的AMPK活化剂,在活化AMPK方面比A769662的效力高5-10倍。 了解更多
  14. MK8722

    Catalog No. A13392
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    pan-AMPK activator
    MK8722 is a potent and systemic pan-AMPK activator. 了解更多
  15. ZLN024

    Catalog No. A21963
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    AMPK allosteric activator
    ZLN024 is an AMPK allosteric activator. 了解更多

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