Crisaborole (AN2728)

Name: Crisaborole (AN2728)
SKU: A12776

目录号: A12776

PDE4 抑制剂?

Crisaborole (AN2728) Chemical Structure

CAS NO. 906673-24-3

AN2728是一种局部给药的含硼抗炎化合物，可抑制PDE4活性，从而抑制TNFalpha，IL-12，IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。

库存：现货

规格	价格	数量
10 mg	￥ 400.00
50 mg	￥ 550.00

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生物活性

AN2728是一种局部给药的含硼抗炎化合物，可抑制PDE4活性，从而抑制TNFalpha，IL-12，IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。

溶解度 *

In vitro	DMSO	47 mg/mL (187.21 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	39.83 mL	199.14 mL	398.28 mL
0.5 mM	7.97 mL	39.83 mL	79.66 mL
1 mM	3.98 mL	19.91 mL	39.83 mL
5 mM	0.8 mL	3.98 mL	7.97 mL

*The above data is based on the productmolecular weight 251.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12776
作用机制	Inhibitor (抑制剂)
M. Wt	251.08
Formula	C14H10BNO3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	906673-24-3
Synonyms	AN 2728, AN-2728
SMILES	B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O