“angiotensin receptors”的搜索结果
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angiotensin 1 (AT1) and AT2 receptor agonist
Angiotensin III is an angiotensin 1 (AT1) and AT2 receptor agonist.
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Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.
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Angiotensin 1/2 + A (2 - 8)有效的内源性血管收缩肽;血管紧张素(Ang)的衍生物II。
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Angiotensin 1/2 (1-6)是一种包含氨基酸1-6的肽,是从血管紧张素I/II肽转化而来的。
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Angiotensin 1/2 (1-5)是一种包含氨基酸1-5的肽,是从血管紧张素I/II转化而来的。
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Angiotensin 1/2 (1-9)是一种肽(ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS),包含从血管紧张素I/II肽转换而来的氨基酸1-9。
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Angiotensin III (human,mouse)是在血管紧张素II的N末端裂解形成的六肽,血管紧张素II是位于红细胞和大多数组织血管床中的血管紧张素酶在肾素-血管紧张素-醛固酮(RAAS)系统中的关键因素。
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Angiotensin II是一种八肽激素,在心血管稳态中起着核心作用。
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Angiotensin (1-7)是一种内源性肽片段,可以分别通过内切肽酶或羧肽酶从Ang I或Ang II产生。
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non-peptide angiotensin II receptor antagonist
Fimasartan is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Through oral administration, fimasartan blocks angiotensin II receptor type 1 (AT1 receptors), reducing pro-hypertensive actions of angiotensin II, such as systemic vasoconstriction and water retention by the kidneys.
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Angiotensin II receptor antagonist
Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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Angiotensin I (human,mouse,rat)是由肾素对血管紧张素原的作用形成的。
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angiotensin II receptor antagonist
EMD-66684 is a non-peptide angiotensin II receptor antagonist.
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nonpeptide angiotensin II receptor antagonist
L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.
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angiotensin AT1 receptor antagonist
L162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM.
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angiotensin II receptor antagonist
CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research.
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angiotensin II receptor antagonist
Pratosartan is a selective angiotensin II receptor antagonist.
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angiotensin-(1-7) receptor agonist
AVE 0991 is a nonpeptide and orally active angiotensin-(1-7) receptor agonist with an IC50 of 21 nM.
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angiotensin II type 1 receptor antagonist
Azilsartan D5 is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.
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angiotensin II receptor antagonist
Losartan D4 Carboxylic Acid is the deuterium labeled Losartan(EXP-3174), which is an angiotensin II receptor antagonist.
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Angiotensin-II subtype 2 receptor(AT2 R) agonist
CGP-42112(CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist.
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angiotensin-converting enzyme inhibitor
Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.
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angiotensin II and endothelin A receptor antagonist
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.
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angiotensin II receptor type 1 antagonist
Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
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angiotensin II receptor antagonist
Valsartan (CGP-48933) is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.
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Angiotensin AT1 receptor antagonist
SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.
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kainate receptors agonist
SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively.
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5-HT1B/1D receptors agonist
Alniditan is a potent 5-HT1B/1D receptors agonist, with IC50 of 1.7 and 1.3 nM in HEK?293 cells, and pKi value of 8.96 and 9.40 for 5-HT1B/1D receptors, respectively.
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GPR119 receptors agonist
PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 uM, respectively.
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5-HT2A and 5-HT2C receptors antagonist
Deramciclane has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist.
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opioid receptors agonist
DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively.
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AChE /M1/M2/5HT4/I2 inhibitor
MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
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Serotonin receptors agonist
Dihydroergotamine Mesylate, also known as DHE or Migranal, is an ergot alkaloid used to treat migraines. It has similar actions to the triptans, acting as an agonist to the serotonin receptors and causing vasoconstriction of the intracranial blood vessels, but also interacts centrally with dopamine and adrenergic receptors.
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Elisartan is an orally active non-peptide pro-drug of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities.
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ACE inhibitor
Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity.
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AT1 receptor antagonist
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
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ACE inhibitor
Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities.
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ACE inhibitor
NCX899 is a NO-releasing derivative of enalapril, and shows inhibitory activity against angiotensin-converting enzyme (ACE) activity.
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H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE)with an IC50 of 5 μM. Antihypertensive tripeptides.
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AT2R antagonist
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist.
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Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog.
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ACE inhibitor
Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.
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ACE inhibitor
Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 81 μM.
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neprilysin (NEP) inhibitor
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.
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ACE inhibitor
H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
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apelin agonist
Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions.
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angiotensin II receptor type 1 拮抗剂
Azilsartan medoxomil是一种口服给药的1型血管紧张素II受体拮抗剂,IC50为0.62 nM。
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angiotensin II receptor 拮抗剂
BIBS39是一种非肽血管紧张素II(AII)受体拮抗剂,可从其特异性结合位点置换[125I] AII,其AII亚型(AT1)受体和K(i)的K(i)值为29+/-7 nM。)AII亚型2(AT2)受体的480+/-110 nM)值。
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angiotensin receptor-neprilysin 抑制剂
LCZ696 (Valsartan)是一种生物利用型双效血管紧张素受体-中性溶血素抑制剂(ARNi),用于治疗高血压和心力衰竭。
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