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Antifection

Antifection

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Rolitetracycline

Catalog No. A13851
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Rolitetracycline是四环素抗生素。了解更多

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Demeclocycline HCl

Catalog No. A14254
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Demeclocycline HCl是一种四环素抗生素，通过抑制细菌的蛋白质合成。了解更多

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Micafungin Sodium

Catalog No. A14246
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1,3-beta-D-glucan synthesis 抑制剂

Micafungin Sodium是1，3-β-D-葡聚糖合成的抑制剂。了解更多

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Mefloquine HCl

Catalog No. A14237
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Mefloquine HCl是一种通过抑制血zo素形成的血裂剂。了解更多

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Erythromycin Cyclocarbonate

Catalog No. A14228
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Erythromycin Cyclocarbonate是红霉素的衍生物，它通过结合50S核糖体来抑制细菌的蛋白质合成。是红霉素的衍生物，它通过结合50S核糖体来抑制细菌的蛋白质合成。了解更多

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TMC353121

Catalog No. A11585
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RSV fusion 抑制剂

TMC353121是一种有效的体外RSV融合抑制剂，pEC50 为 9.9。抗病毒药，也是治疗RSV疾病的新型候选药物。了解更多

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Butenafine HCl

Catalog No. A11829
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Butenafine Hydrochloride是一种抗真菌药，可用于控制皮肤真菌感染，例如运动员的足癣和癣菌。了解更多

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Calcitetrol

Catalog No. A11362
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Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。了解更多

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Ganciclovir

Catalog No. A11645
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Ganciclovir是一种用于猫疱疹病毒1型的抗病毒药物，IC50为5.2μM。了解更多

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Isoconazole nitrate

Catalog No. A10481
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Isoconazole nitrate (Travogen)是一种唑类抗真菌剂。了解更多

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Cloxacillin sodium

Catalog No. A10235
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Cloxacillin sodium是一种与青霉素同属的半合成抗生素。氯西林用于抗产生β-内酰胺酶的葡萄球菌，因为它的R链较大，不允许β-内酰胺酶结合。了解更多

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
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Chlortetracycline Hydrochloride

Catalog No. A11927
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Chlortetracycline Hydrochloride是一种特殊而有效的钙离子载体抗生素。了解更多

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Tigecycline

Catalog No. A10933
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Tigecycline具有抑菌作用，是一种蛋白质合成抑制剂，可与细菌的30S核糖体亚基结合，从而在原核翻译过程中阻止氨酰tRNA进入核糖体的A位点。了解更多

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- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Xiaoming Liu, .et al. Comparison of antibacterial activities and resistance mechanisms of omadacycline and tigecycline against Enterococcus faecium, J Antibiot (Tokyo), 2022, Aug;75(8):463-471 PMID: 35760902
- Sato T, .et al. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages, Microb Drug Resist, 2018, Jul/Aug;24(6):860-867 PMID: 29232167
- Dinah B. Aziz, .et al. Teicoplanin ?C Tigecycline Combination Shows Synergy Against Mycobacterium abscessus, Front Microbiol, 2018, May 11 PMID: 29867841
- Toyotaka Sato, .et al. Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648, Antimicrob Agents Chemother, 2017, Feb; 61(2): e01654-16 PMID: 27855067
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Oseltamivir phosphate (Tamiflu)

Catalog No. A11653
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Oseltamivir phosphate (Tamiflu)是一种抗病毒药，可以通过阻止病毒与其宿主细胞发生化学切断来减慢流感病毒在人体内细胞之间的传播。了解更多

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Cefoselis sulfate

Catalog No. A10189
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Cefoselis sulfate是一种广泛使用的β-内酰胺抗生素。了解更多

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Aztreonam (Azactam, Cayston)

Catalog No. A10118
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Aztreonam (Azactam,Cayston)是一种合成的单环β-内酰胺抗生素 (一种单bactam)，其细胞核是基于一种从紫罗兰色杆菌中分离出来的更简单的单bactam。了解更多

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- Sreevalli Sharma, .et al. Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria, ACS Infect Dis, 2021, Nov 12;7(11):3009-3024 PMID: 34699190
- Pholwat S, .et al. Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens, PLoS One, 2019, May 10;14(5):e0216747 PMID: 31075137
- Robert Bucki, .et al. Targeting polyelectrolyte networks in purulent body fluids to modulate bactericidal properties of some antibiotics, Infect Drug Resist, 2018, 11: 77-86 PMID: 29391814
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Amphotericin B

Catalog No. A10073
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Amphotericin B是来自链霉菌属的多烯抗真菌抗生素。Amphotericin B诱导K+泄漏，这与其致死作用是分开的，正如在人类红细胞中所证明的，这是由于对Na+/K+泵的抑制作用所致。了解更多

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- J Chen, .et al. Exosomal miRNA-486-5p Derived From Rheumatoid Arthritis Fibroblast-Like Synoviocytes Induces Osteoblast Differentiation Through the Tob1/BMP/Smad Pathway, Biomater Sci, 2020, Jun 21;8(12):3430-3442 PMID: 32406432
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Amorolfine HCl

Catalog No. A10072
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Antifungal compound

Amorolfine hydrochloride是一种吗啉类抗真菌药，可抑制D14还原酶和D7-D8异构酶，这些酶消耗麦角固醇并导致木质甾醇在真菌细胞质细胞膜中积聚。了解更多

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Linezolid (PNU-100766)

Catalog No. A10533
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Protein synthesis 抑制剂

Linezolid是一种用于治疗严重感染的合成抗生素。了解更多

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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Peramivir

Catalog No. A11124
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Neuraminidase 抑制剂

Peramivir是一种神经氨酸酶抑制剂，可作为流感神经氨酸酶的过渡态类似物抑制剂，从而防止新病毒从受感染的细胞中出现。了解更多

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- Daisuke Kato, .et al. An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac, PLoS One, 2018, 13(7): e0200761 PMID: 30001430
- Yuuki Kurebayashi, .et al. High-Efficiency Capture of Drug Resistant-Influenza Virus by Live Imaging of Sialidase Activity, PLoS One, 2016, 11(5): e0156400 PMID: 27232333
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Retapamulin (SB-275833)

Catalog No. A11139
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Antibacterial agent

Retapamulin (SB-275833)是一种抗菌剂，特别是蛋白质合成抑制剂。了解更多

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- Merianne Mohamad, .et al. Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci, Nucleic Acids Res, 2022, Feb 28;50(4):2128-2142 PMID: 35137182
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PA-824 (Pretomanid)

Catalog No. A11401
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PA-824 (Pretomanid)是一种实验性抗结核药物，MIC为<1 μg/mL。了解更多

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- Wang X, .et al. Antitubercular Triazines: Optimization and Intrabacterial Metabolism, Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854
- Alexandre López-Gavín, .et al. In vitro activity against Mycobacterium tuberculosis of levofloxacin, moxifloxacin and UB-8902 in combination with clofazimine and pretomanid., Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981
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Ansatrienin B

Catalog No. A16072
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Ansatrienin B是含有三烯结构的安沙霉素抗生素。了解更多

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Chlorothricin

Catalog No. A16070
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Chlorothricin是丙酮酸羧化酶的螺酮酸抗生素抑制剂。了解更多

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Dalbavancin HCl

Catalog No. A15948
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Dalbavancin HCl是一种新型的第二代脂肽抗生素。了解更多

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Calicheamicin

Catalog No. A15943
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Calicheamicin是一种有效的烯二炔抗肿瘤抗生素，衍生自细单孢菌。Calicheamicin靶向DNA并引起链断裂。了解更多

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Presatovir (GS-5806)

Catalog No. A15835
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Antiviral fusion 抑制剂

Presatovir (GS-5806)是一种新型的，生物利用的RSV融合抑制剂，可抗多种RSV A和B临床分离株（平均EC50 = 0.43 nM）。了解更多

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Sodium Tauroursodeoxycholate

Catalog No. A15909
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Sodium Tauroursodeoxycholate是一种水溶性胆汁盐，用于治疗胆结石和肝硬化。了解更多

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- Stella Liong, .et al. Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women, Mol Cell Endocrinol, 2016, Apr 15;425:11-25 PMID: 26902174
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Fiacitabine

Catalog No. A11422
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HSV DNA replication 抑制剂

Fiacitabine是单纯疱疹病毒(HSV)DNA复制的选择性抑制剂，HSV1和HSV2的IC50值分别为2.5 nM和12.6 nM。了解更多

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Rifamycin S

Catalog No. A15831
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Rifamycin S是一组由细菌利福霉素支原体天然合成或人工合成的抗生素。发现利福霉素S对革兰氏阳性菌非常有效，最小抑菌浓度为0.0025 ug/ml。了解更多

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TBA-354

Catalog No. A15431
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anti-tuberculosis

TBA-354是一种有效的抗结核化合物；维持针对结核分枝杆菌H37Rv同基因单抗菌株以及临床药物敏感和耐药菌株的活性。了解更多

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Sancycline

Catalog No. A13393
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Sancycline像其他四环素类药物一样，三环素通过可逆地结合到30S核糖体亚单位并通过阻断氨酰tRNA进入核糖体A位点来抑制蛋白质翻译。了解更多

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SQ109

Catalog No. A12485
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SQ109是一种口服活性小分子抗生素，IC50 为 50±8 nM，用于治疗肺部T（结核病）。了解更多

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Ascomycin (FK520)

Catalog No. A15788
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Calcineurin/PP2B 抑制剂

Ascomycin (FK520)是他克莫司的乙基类似物（FK506），具有强的免疫抑制特性。已经研究出其用于治疗自身免疫疾病和皮肤疾病，并防止器官移植后的排斥反应。了解更多

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Oritavancin (LY333328)

Catalog No. A15771
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Oritavancin (LY333328)是一种新型的半合成糖肽抗生素。2014年8月6日，FDA批准奥利万星用于治疗皮肤感染。奥利万星在体外具有对各种耐药和易感革兰氏阳性细菌（包括金黄色葡萄球菌，MRSA，肠球菌和链球菌）的有效且快速的杀菌活性。了解更多

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Laninamivir (CS-8958)

Catalog No. A12998
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Neuraminidase 抑制剂

Laninamivir (CS-8958)是一种神经氨酸酶抑制剂，正在研究用于治疗和预防A型流感病毒和B型流感病毒。其对流感病毒 H12N5 NA (N5)，pH1N1 N1 NA (p09N1) 和 A/RI/5+/1957 H2N2 N2 (p57N2) 的 IC50 分别为 0.90 nM、1.83 nM 和 3.12 nM。了解更多

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Moxidectin

Catalog No. A12459
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Moxidectin是一种杀灭寄生虫(蠕虫)的驱肠虫药物，用于预防和控制心蠕虫和肠蠕虫。了解更多

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AN-2690

Catalog No. A14999
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AN-2690是一种抗真菌剂，在局部溶液制剂中具有对抗毛癣菌物种的活性。了解更多

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Amadacycline methanesulfonate

Catalog No. A14996
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Amadacycline methanesulfonate是正在开发的新型四环素抗生素，可以抑制细菌核糖体的30s亚基。了解更多

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Amadacycline

Catalog No. A14995
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Amadacycline是正在开发的新型四环素抗生素，可以抑制细菌核糖体的30s亚基。了解更多

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I2906

Catalog No. A15120
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I2906对结核分枝杆菌显示出抗分枝杆菌和细胞毒活性。了解更多

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(S)-Tedizolid

Catalog No. A14965
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Torezolid是恶唑烷酮类药物的II期临床试验，用于复杂的皮肤和皮肤结构感染（cSSSI），包括由耐甲氧西林的金黄色葡萄球菌（MRSA）引起的感染。了解更多

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Imipenem

Catalog No. A14942
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Imipenem是一种默克科学家伯顿·克里斯滕森（Burton Christensen），威廉·利安扎（William Leanza）和肯尼思·怀唐格（Kenneth Wildonger）于1980年发现的静脉内使用的内酰胺类抗生素。了解更多

Product Citations (4)

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Hongwei Liu, .et al. Evidence for the plant recruitment of beneficial microbes to suppress soil-borne pathogens, New Phytol, 2020, Oct 31 PMID: 33131088
- Pholwat S, .et al. Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens, PLoS One, 2019, May 10;14(5):e0216747 PMID: 31075137
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
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Eperezolid

Catalog No. A13486
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Eperezolid是恶唑烷酮抗生素。不论甲氧西林对葡萄球菌的敏感性如何（MIC90 = 1-4 mg/ml），它都具有良好的体外抑制活性。了解更多

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Solithromycin

Catalog No. A14031
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Solithromycin是一种新型的酮内酯抗生素。Solithromycin（CAS 760981-83-7）可用于抗感染，并且有望成为20多年来可用于静脉，口服和儿科悬浮液制剂的首个大环内酯类抗生素。了解更多

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Ganciclovir Mono-O-acetate

Catalog No. A13543
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Ganciclovir Mono-O-acetate是更昔洛韦衍生物。了解更多

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DL-cycloserine

Catalog No. A13612
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DL-cycloserine是一种抗菌剂。了解更多

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