AZ 3146

Name: AZ 3146
SKU: A11170

目录号: A11170

Mps1 抑制剂

Product Citations (4)

AZ 3146 Chemical Structure

CAS NO. 1124329-14-1

AZ 3146是一种有效的选择性单极纺锤体1 (Mps1) 激酶抑制剂 (IC50 = 35 nM) 。它会干扰染色体对齐并覆盖纺锤体装配检查点，还抑制将Mad1，Mad2和着丝粒蛋白E（CENP-E）募集到动植物。

库存：现货

规格	价格	数量
5 mg	￥ 500.00
10 mg	￥ 800.00
50 mg	￥ 2,400.00
100 mg	￥ 4,500.00
10mM * 1mL in DMSO	￥ 900.00

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生物活性

靶点信息

Mps1
~35 nM

溶解度 *

In vitro	DMSO	27 mg/mL (59.66 mM)
	Water	Insoluble
	Ethanol	87 mg/mL (192.24 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.1 mL	110.49 mL	220.97 mL
0.5 mM	4.42 mL	22.1 mL	44.19 mL
1 mM	2.21 mL	11.05 mL	22.1 mL
5 mM	0.44 mL	2.21 mL	4.42 mL

*The above data is based on the productmolecular weight 452.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11170
作用机制	Inhibitor (抑制剂)
M. Wt	452.55
Formula	C24H32N6O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1124329-14-1
Synonyms	AZ-3146
SMILES	CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC