产品详情
Targets
Target | Value |
---|---|
EGFR(L858R/T790M) | IC50: <1nM |
EGFR(L861Q) | IC50: 1nM |
EGFR(L858R) | IC50: 6nM |
ErbB4 | IC50: 7nM |
EGFR(wildtype) | IC50: 25nM |
ACK1 | IC50: 27nM |
BLK | IC50: 27nM |
BRK | IC50: 45nM |
MNK2 | IC50: 62nM |
IGF1-R | IC50: 78nM |
ALK | IC50: 97nM |
TEC | IC50: 118nM |
FES | IC50: 127nM |
InsR | IC50: 127nM |
FLT3 | IC50: 129nM |
BTK | IC50: 132nM |
FAK | IC50: 136nM |
MLK1 | IC50: 141nM |
FLT4 | IC50: 142nM |
PYK2 | IC50: 284nM |
IRR | IC50: 423nM |
Txk | IC50: 426nM |
BMX | IC50: 505nM |
ITK | IC50: 925nM |
JAK3 | IC50: 1358nM |
In vitro (25°C) | DMSO | 90 mg/mL (185.34 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 21 mg/mL (43.24 mM) | ||
In vivo | 1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.59 mL | 102.97 mL | 205.94 mL |
0.5 mM | 4.12 mL | 20.59 mL | 41.19 mL |
1 mM | 2.06 mL | 10.3 mL | 20.59 mL |
5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A15516 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 485.58 |
Formula | C27H31N7O2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1421373-98-9 |
Synonyms | AZ-5104, AZ 5104 |
SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC |
产品标签
Product Questions
Product Questions
ALK-IN-1 (Brigatinib analog, AP26113 analog)
AP26113是一种有效的,选择性的ALK抑制剂,对野生型的功效为0.62 nM,对包括crizotinib耐药的L1196M系在内的多…
AG-1478 (Tyrphostin AG-1478)
AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂,IC50值为3 nM。
ARRY334543 (Varlitinib)
ARRY334543 (Varlitinib)是一种有效的EGFR和ErbB-2口服活性小分子抑制剂。
ASP8273 (Naquotinib)
ASP8273 (Naquotinib)是不可逆的,第三代,选择性突变的表皮生长因子受体(EGFR)抑制剂,具有潜在的抗肿瘤…
AZD-9291 (Osimertinib)
AZD-9291 (Osimertinib)是第三代EGFR抑制剂,在临床前研究中显示出希望,并为已对现有EGFR抑制剂产生耐药性的…