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AZD1152是一种前药，可在血清中迅速经历磷酸酶介导的裂解作用，释放出Barasertib-hQPA（一种选择性的Aurora B激酶抑制剂），在急性髓细胞性白血病（AML）患者的临床研究中显示出初步活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.02 mL | 85.1 mL | 170.2 mL |
| 0.5 mM | 3.4 mL | 17.02 mL | 34.04 mL |
| 1 mM | 1.7 mL | 8.51 mL | 17.02 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 587.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15011 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 587.54 |
| Formula | C26H31FN7O6P |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 722543-31-9 |
| Synonyms | Barasertib, AZD-1152, AZD 1152 |
| SMILES | CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCOP(=O)(O)O |
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