AZD3759

目录号: A15551

EGFR 抑制剂

AZD3759

AZD3759 Chemical Structure

CAS NO. 1626387-80-1

AZD3759是表皮生长因子受体(EGFR)的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。

库存: 现货

规格 价格 数量
10 mg
¥ 800.00
25 mg
¥ 1,200.00
50 mg
¥ 1,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AZD3759是表皮生长因子受体(EGFR)的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。
靶点信息
EGFR (L858R) EGFR (exon 19Del) EGFR (WT)
0.2 nM0.2 nM0.3 nM
In vitro DMSO 80 mg/mL (173.94 mM)
Water Insoluble
Ethanol Warmed: 18 mg/mL (39.13 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.74 mL 108.72 mL 217.44 mL
0.5 mM 4.35 mL 21.74 mL 43.49 mL
1 mM 2.17 mL 10.87 mL 21.74 mL
5 mM 0.43 mL 2.17 mL 4.35 mL

*The above data is based on the productmolecular weight 459.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15551
作用机制 Inhibitor (抑制剂)
M. Wt 459.9
Formula C22H23ClFN5O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1626387-80-1
Synonyms AZD 3759
SMILES CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C

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