AZD6244 (Selumetinib)

目录号: A10257

MEK 抑制剂

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) Chemical Structure

CAS NO. 606143-52-6

Selumetinib (AZD6244)是一种有效,高选择性的MEK抑制剂,ARRY142886,AZD-6244和ARRY-142886是MEK 1/2抑制剂,GI50值在14至50 nm之间。

库存: 现货

规格 价格 数量
100 mg
¥ 800.00
250 mg
¥ 1,500.00
500 mg
¥ 2,500.00
10mM * 1mL in DMSO
¥ 640.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Selumetinib (AZD6244)是一种有效,高选择性的MEK抑制剂,ARRY142886,AZD-6244和ARRY-142886是MEK 1/2抑制剂,GI50值在14至50 nm之间。
靶点信息
MEK1 (Cell-free assay)
14 nM
In vitro (25°C) DMSO Warmed: 80 mg/mL (174.79 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.85 mL 109.24 mL 218.48 mL
0.5 mM 4.37 mL 21.85 mL 43.7 mL
1 mM 2.18 mL 10.92 mL 21.85 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10257
作用机制 Inhibitor (抑制剂)
M. Wt 457.7
Formula C17H15BrClFN4O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 606143-52-6
Synonyms ARRY-142886
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO

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