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BI-847325

MEK/Aurora 抑制剂

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产品目录号: A15762

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BI-847325 5mg A15762-5
¥ 1,050.00
BI-847325 10mg A15762-10
¥ 1,800.00
BI-847325 25mg A15762-25
¥ 3,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

BI-847325

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Chemical Information

目录号 A15762
Mechanism of action Inhibitor
分子量 464.56
化学分子式 C29H28N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1207293-36-4
Synonyms BI 847325, BI847325
SMILES code CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O
化学名称 (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide

Biological Activity

Description
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Targets
Aurora B (Xenopus laevis) MEK2 Aurora C (Human) Aurora A (Human) MEK1
3 nM4 nM15 nM25 nM25 nM

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