产品详情

生物活性

BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率，同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。

靶点信息

CSF-1R
1 nM

溶解度 *

In vitro (25°C)	DMSO	77 mg/mL (193.23 mM)
	Water	Insoluble
	Ethanol	Warmed: 3 mg/mL
In vivo	4% DMSO+30% PEG 300+ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.1 mL	125.5 mL	251 mL
0.5 mM	5.02 mL	25.1 mL	50.2 mL
1 mM	2.51 mL	12.55 mL	25.1 mL
5 mM	0.5 mL	2.51 mL	5.02 mL

*The above data is based on the productmolecular weight 398.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15540
作用机制	Inhibitor (抑制剂)
M. Wt	398.4
Formula	C20H22N4O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	953769-46-5
Synonyms	BLZ 945, BLZ-945
SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O