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BMS-794833是Met和VEGFR-2的有效ATP竞争性抑制剂，IC50为1.7和15 nM。
靶点信息
| Met | VEGFR2 | |||
| 1.7 nM | 15 nM |
| In vitro | DMSO | 85 mg/mL (181.29 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.33 mL | 106.66 mL | 213.31 mL |
| 0.5 mM | 4.27 mL | 21.33 mL | 42.66 mL |
| 1 mM | 2.13 mL | 10.67 mL | 21.33 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
*The above data is based on the productmolecular weight 468.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10154 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 468.8 |
| Formula | C23H15ClF2N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1174046-72-0 |
| Synonyms | BMS794833 |
| SMILES | C1=CC(=CC=C1C2=CNC=C(C2=O)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F)F |
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