BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. 了解更多

Bone Morphogenetic protein-5 Human Recombinant 了解更多

Bone Morphogenetic Protein-7 Human Recombinant, His Tag 了解更多

Bone Morphogenetic Protein-2 Human Recombinant, Monomer 了解更多

Bone Morphogenetic Protein-4 Human Recombinant 了解更多

Bone Morphogenetic Protein-7 Human Recombinant 了解更多

Bone Morphogenetic Protein-7 Human Recombinant, CHO 了解更多

Bone Morphogenetic Protein-2 Human Recombinant 了解更多

Bone Morphogenetic protein-6 Human Recombinant, Hek 了解更多

Bone Morphogenetic protein-7 Human Recombinant, HEK 了解更多

Bone Morphogenetic protein-4 Human Recombinant, Active 了解更多

Bone Morphogenetic protein-2 Human Recombinant, HEK 了解更多

Bone Morphogenetic Protein-7 Human Recombinant, Plant 了解更多

Bone Morphogenetic Protein-7 Polyclonal Rabbit Anti Human Antibody 了解更多

Bone Morphogenetic protein-2, Mouse Anti-Human 了解更多

SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules. 了解更多

LDN193189 HCl (DM-3189) is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β. 了解更多

p53和MDM2蛋白相互作用抑制剂消旋体是p53和MDM2蛋白之间相互作用的抑制剂。 了解更多

p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。 了解更多

LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC50??500 nM). 了解更多

Bone Morphogenetic protein-13 Human Recombinant 了解更多

Bone Morphogenetic protein-3 Human Recombinant 了解更多

Bone Morphogenetic protein Receptor-1B Human Recombinant 了解更多

Bone Morphogenetic protein-6 Human Recombinant 了解更多

Bone Morphogenetic Protein Receptor Type IA Human Recombinant 了解更多

Bone Morphogenetic protein-10 Human Recombinant 了解更多

Bone Morphogenetic protein Receptor-1A Human Recombinant, IgG-His 了解更多

Bone Morphogenetic protein-8b Human Recombinant 了解更多

Bone Morphogenetic protein-8b, Mouse Anti Human 了解更多

Bone Morphogenetic Protein-7, Mouse Anti Human 了解更多

Thrombin is a trypsin-like allosteric serine protease. Thrombin enables site-specific cleavage of fusion proteins with an accessible Thrombin recognition sequence and can be used to digest GST-tagged proteins. 了解更多

Alisol B is a potentially novel therapeutic compound for bone disorders by targeting the differentiation of osteoclasts as well as their functions. 了解更多

MBC-11 is a first-in-class conjugate of the bone-targeting bisphosphonate etidronate covalently linked to the antimetabolite cytarabine (araC). Has potential to treat tumor-induced bone disease (TIBD). 了解更多

MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. Has potential to treat tumor-induced bone disease (TIBD). 了解更多

Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget??s disease of bone (PDB). Neridronate is effective also in other skeletal diseases such as osteoporosis, algodystrophy, hypercalcemia of malignancy, and bone metastases. 了解更多

GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. 了解更多

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity. 了解更多

Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. 了解更多

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). 了解更多

5'-GTP trisodium salt hydrate is an activator of the signal transducing G proteins and also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA. 了解更多

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis. 了解更多

Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses. 了解更多

Anisindione (brand name Miradon) is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K?Cmediated gamma-carboxylation of precursor proteins. 了解更多

Cefamandole nafate is a pro-drug that is hydrolyzed by plasma esterases to produce cefamandole, second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole nafate is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. 了解更多

L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. 了解更多

Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. 了解更多

Smurf1-IN-A01 (A01) is an ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) inhibitor with a kd of 3.664 nM, which increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. 了解更多

Dorsomorphin 2HCl (BML-275)是BMP信号传导的选择性小分子抑制剂，可促进胚胎干细胞的心肌发生。Dorsomorphin通过抑制骨形态发生蛋白信号转导逆转乳腺癌起始细胞的间质表型。 了解更多

K02288是一种有效的选择性I型BMP受体抑制剂，对ALK2，ALK1和ALK6的IC50为1.1、1.8、6.4 nM。 了解更多