Brigatinib (AP26113)

Name: Brigatinib (AP26113)
SKU: A13450

目录号: A13450

ALK 抑制剂

Brigatinib (AP26113) Chemical Structure

CAS NO. 1197953-54-0

Brigatinib (AP26113)是一种有效的选择性ALK（IC50，0.6 nM）和ROS1（IC50，0.9 nM）抑制剂。它还以较低的效力抑制ROS1，FLT3和FLT3（D835Y）和EGFR的突变体。

库存：现货

规格	价格	数量
5 mg	￥ 450.00
10 mg	￥ 650.00
25 mg	￥ 1,200.00

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生物活性

Brigatinib (AP26113)是一种有效的选择性ALK（IC50，0.6 nM）和ROS1（IC50，0.9 nM）抑制剂。它还以较低的效力抑制ROS1，FLT3和FLT3（D835Y）和EGFR的突变体。

溶解度 *

In vitro	DMSO	Warmed: 1 mg/mL (1.71 mM)
	Water	Insoluble
	Ethanol	Warmed: 39 mg/mL (66.76 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.12 mL	85.6 mL	171.21 mL
0.5 mM	3.42 mL	17.12 mL	34.24 mL
1 mM	1.71 mL	8.56 mL	17.12 mL
5 mM	0.34 mL	1.71 mL	3.42 mL

*The above data is based on the productmolecular weight 584.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13450
作用机制	Inhibitor (抑制剂)
M. Wt	584.09
Formula	C29H39ClN7O2P
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1197953-54-0
Synonyms	AP-26113, AP 26113, AP26113
SMILES	CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC