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Casein Kinase

Inhibitory Selectivity
Catalog No.Inhibitor Name CK1CK2Other
A11060Silmitasertib
***
A13949D 4476
**
ALK5
A16235SR-3029
**
A15764IC 261
*
A15257TBB
*
A15069DMAT
**
A16236TA-01
***
p38α
A14101TTP-22
**
JNK3, ROCK1, and MET
A13574 LH 846
**
A11781PF 670462
***
A13977TMCB
**
ERK8

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11060 SALE

CX-4945 (Silmitasertib)

CK2 抑制剂
CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
A16236

TA-01

CK 抑制剂
TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).
A16235

SR-3029

CK1??/CK1?? 抑制剂
SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM.
A16234

CX-4945 sodium salt

CK2 抑制剂
CX-4945 sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.
A15764 SALE

IC 261

CK1?? and CK1?? 抑制剂
IC 261 is CK1δ and CK1ε inhibitor.
A15257

TBB

CK2 抑制剂
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 uM for rat liver and human recombinant CK2 respectively).
A15069 SALE

DMAT

CK2 抑制剂
DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM.
A14101

TTP-22

CK2 抑制剂
TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
A13949 SALE

D4476

CK1 抑制剂
D4476 is a cell-permeant inhibitor of casein kinase 1.
A13574

LH 846

CK1 抑制剂
LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α)
A11781

PF 670462

Casein kinase 抑制剂
Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
A10344 SALE

Ellagic acid

-
Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.
A13584

A-3 Hydrochloride

PKA, PKG, Casein Kinase I and II 抑制剂
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
A13977

TMCB

CK2/ERK8 抑制剂
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).

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