“akt”的搜索结果

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  1. AKT-IN-1

    Catalog No. A21009
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    AKT inhibitor
    AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. 了解更多
  2. AKT Kinase Inhibitor

    Catalog No. A11285
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    Akt kinase inhibitor
    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity. 了解更多
  3. AKT-IN-2

    Catalog No. A20147
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    AKT inhibitor
    AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1. 了解更多
  4. AKT inhibitor VIII (AKTI-1/2)

    Catalog No. A11286
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    AKT 抑制剂
    AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物,在体外激酶测定中,该化合物有效和选择性地抑制Akt1/Akt2活性(对于Akt1,Akt2和Akt3,IC50分别为58 nM,210 nM和2.12μM)。 了解更多
  5. PF-AKT400

    Catalog No. A21991
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    Akt inhibitor
    PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). 了解更多
  6. Akt-l-1

    Catalog No. A12435
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    AKT1 抑制剂
    Akt-I-1是Akt1(IC50为4.6 μM)的特异性抑制剂,不抑制AKT2或AKT3。 了解更多
  7. AdScreen™ PI3K/Akt/mTOR Inhibitor Compound Library

    Catalog No. CPL002
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  8. API-1

    Catalog No. A22093
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    Akt inhibitor
    API-1 (NSC 177223) is a potent inhibitor of Akt that induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. 了解更多
  9. Miransertib hydrochloride

    Catalog No. A22376
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    Akt inhibitor
    Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. 了解更多
  10. Ipatasertib dihydrochloride

    Catalog No. A21734
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    pan-Akt inhibitor
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA. 了解更多
  11. YS-49

    Catalog No. A21198
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    PI3K/Akt activator
    YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. 了解更多
  12. Solenopsin

    Catalog No. A21087
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    ATP-competitive AKT inhibitor
    Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM . 了解更多
  13. OSU-T315

    Catalog No. A20870
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    ILK inhibitor
    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). 了解更多
  14. Isobavachalcone

    Catalog No. A11453
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    Akt inhibitor
    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). 了解更多
  15. Borussertib

    Catalog No. A13364
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    Akt inhibitor
    Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt. 了解更多
  16. 10-DEBC HCl

    Catalog No. A13590
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    AKT/PKB 抑制剂?
    10-DEBC HCl是Akt/PKB的选择性抑制剂。它抑制IGF-1刺激的磷酸化和Akt的激活(在2.5μM时完全抑制),抑制mTOR,p70 S6激酶的下游激活。 了解更多
  17. WAY-600

    Catalog No. A11188
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    mTOR 抑制剂
    WAY-600是一种有效的,ATP竞争性的,选择性的mTOR抑制剂,IC50为9 nM;抑制mTORC1/P-S6K(T389)和mTORC2/P-AKT(S473),但不抑制P-AKT(T308);作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。 了解更多
  18. WYE-687

    Catalog No. A11187
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    mTOR 抑制剂
    WYE-687是雷帕霉素(mTOR)哺乳动物靶标的新型ATP竞争性和选择性抑制剂,IC50为7 nM;抑制mTORC1/pS6K(T389)和mTORC2/P-AKT(S473),但不抑制P-AKT(T308),作用于mTOR比作用于PI3Kα(>100倍)和PI3Kγ(>500倍)选择性高。 了解更多
  19. Palomid 529 (P529)

    Catalog No. A10693
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    AKT 抑制剂
    Palomid 529是PI3K/Akt/mTOR途径的双重TORC1/2抑制剂,在血管生成和细胞增殖中具有广泛的活性。 了解更多
  20. 3-Hydroxyanthranilic acid

    Catalog No. A22292
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    immunomodulatory agent
    3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators. 了解更多
  21. Loureirin A

    Catalog No. A22313
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    flavonoid
    Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. 了解更多
  22. Rotundic acid

    Catalog No. A22390
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    anti-inflammatory agent
    Rotundic acid, a triterpenoid obtained from I. rotunda, induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities. 了解更多
  23. Periplocin

    Catalog No. A22448
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    antitumor agent
    Periplocin is a cardiotonic steroid isolated from Periploca forrestii. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase. 了解更多
  24. Asperosaponin VI

    Catalog No. A14474
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    osteoblast differentiation inducer
    Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. 了解更多
  25. ML-9 hydrochloride

    Catalog No. A17856
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    MLCK inhibitor
    ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation. 了解更多
  26. Recilisib (free acid)

    Catalog No. A20255
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    radioprotectant
    Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells. 了解更多
  27. Guggulsterone

    Catalog No. A19825
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    Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. 了解更多
  28. LM22B-10

    Catalog No. A19485
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    TrkB/TrkC neurotrophin receptor activator
    LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo. 了解更多
  29. Rigosertib

    Catalog No. A21868
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    multi-kinase inhibitor
    Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. 了解更多
  30. Rigosertib sodium

    Catalog No. A21824
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    multi-kinase inhibitor
    Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. 了解更多
  31. Cenisertib

    Catalog No. A11262
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    multi-kinase inhibitor
    Cenisertib (AS-703569) is a multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. 了解更多
  32. alpha-Bisabolol

    Catalog No. A18691
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    alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells. 了解更多
  33. N-Oleoyl glycine

    Catalog No. A18717
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    N-Oleoyl glycine is a lipoamino acid, which stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte. 了解更多
  34. RTC-5

    Catalog No. A19067
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    RTC-5 is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling. 了解更多
  35. Afuresertib

    Catalog No. A16392
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    Akt 抑制剂
    Afuresertib是一种有效的口服生物利用性Akt抑制剂,对于Akt1,Akt2和Akt3,Ki分别为0.08 nM,2 nM和2.6 nM。 了解更多
  36. ARQ-092 (Miransertib)

    Catalog No. A16286
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    AKT 抑制剂
    ARQ 092是一种口服活化,有效和选择性的AKT抑制剂,IC50值:5.0 nM(AKT1);4.5 nM(AKT2);16 nM(AKT3)。 了解更多
  37. Akt1 and Akt2-IN-1

    Catalog No. A16285
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    AKT 1/2 抑制剂
    Akt1 and Akt2-IN-1是Akt1(IC50 = 3.5 nM)和Akt2(IC50 = 42 nM)的变构抑制剂,具有有效且平衡的活性。 了解更多
  38. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB 抑制剂
    Tomatidine抑制ERK,Akt的磷酸化以及NF-kB的核含量。具有抗炎特性。 了解更多
  39. TIC10

    Catalog No. A15903
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    Akt 抑制剂?
    TIC10通过Foxo3a使Akt和ERK失活,从而诱导TRAIL,具有优越的药物特性:跨血脑屏障传递,优异的稳定性和改善的药代动力学。 了解更多
  40. SC 66

    Catalog No. A12081
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    Akt 抑制剂
    SC 66是Akt的变构抑制剂,促进Akt的泛素化和失活。它在体外和体内显示抗癌活性。 了解更多
  41. GSK2141795 (Uprosertib, GSK795)

    Catalog No. A15809
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    Akt 抑制剂
    GSK2141795 (Uprosertib,GSK795)结合并抑制Akt的活性,这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导。 了解更多
  42. SC79

    Catalog No. A15541
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    Akt phosphorylation activator
    SC79是AKT激活剂。SC79绑定到模仿PtdIns(3,4,5)P3的结合的Akt的plecktrin同源(PH)域,以诱导Akt的构象变化,从而增强磷酸化和激活。 了解更多
  43. AT7867 2HCl

    Catalog No. A15006
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    Akt 抑制剂
    AT7867 dihydrochloride是一种有效的ATP竞争性Akt1/2/3和p70S6K/PKA抑制剂,IC50分别为32 nM/17 nM/47 nM和85 nM/20 nM,在AGC激酶家族之外几乎没有活性。 了解更多
  44. Afuresertib HCl

    Catalog No. A13030
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    AKT 抑制剂?
    Afuresertib HCl,也称为GSK2110183,是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt(蛋白激酶B)的生物利用抑制剂。它结合并抑制Akt的活性,这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关,PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。 了解更多
  45. SR-13668

    Catalog No. A13554
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    AKT 抑制剂?
    SR-136683是一种口服制剂,其中含有血管内皮生长因子受体(VEGFR)和血小板衍生生长因子受体(PDGFR)的小分子受体酪氨酸激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  46. Miltefosine

    Catalog No. A14138
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    PI3K/Akt 抑制剂
    Miltefosine在癌细胞系A431和HeLa中抑制PI3K/Akt活性,ED50为17.2μM和8.1μM。 了解更多
  47. Piperlongumine

    Catalog No. A14124
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    TrxR1/CRM1 抑制剂
    Piperlongumine,存在于胡椒科植物荜茇中的一种天然生物碱,能够增加reactive oxygen species (ROS)水平,并选择性杀死癌细胞。它还是TrxR1的直接抑制剂,对胃癌具有抑制活性;一种新型的CRM1抑制剂;在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 了解更多
  48. TIC10 isomer

    Catalog No. A12720
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    AKT 抑制剂?
    TIC10通过Foxo3a使Akt和ERK失活,从而诱导TRAIL,具有优越的药物特性:跨血脑屏障传递,优异的稳定性和改善的药代动力学。 了解更多
  49. Triciribine

    Catalog No. A13210
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    AKT 抑制剂
    Triciribine,也称为API-2,可抑制Akt的磷酸化水平和激酶活性。 了解更多
  50. KP372-1

    Catalog No. A12877
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    Akt 抑制剂
    KP372-1是合成的小分子AKT抑制剂。 了解更多

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