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CCT137690

Aurora Kinase 抑制剂

158 Customer Reviews
产品目录号: A11081

库存状态:中国现货中国现货

产品名 目录号 价格 数量
CCT137690 5mg A11081-5
¥ 850.00
CCT137690 10mg A11081-10
¥ 1,100.00
CCT137690 50mg A11081-50
¥ 4,000.00
CCT137690 100mg A11081-100
¥ 6,250.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.

CCT137690

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Chemical Information

目录号 A11081
Mechanism of action Inhibitor
分子量 551.5
化学分子式 C26H31BrN8O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1095382-05-0
Synonyms CCT-137690
SMILES code CC1=CC(=NO1)CN2CCN(CC2)C3=C4C(=NC=C3Br)N=C(N4)C5=CC=C(C=C5)N6CCN(CC6)C
化学名称 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine

Biological Activity

Description
CCT137690 is a highly selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 15 nM, 25 nM and 19 nM. It has little effect on hERG ion-channel.
Targets
Aurora A Aurora C Aurora B
15 nM19 nM25 nM

Solubility

Solubility (25°C) * In vitro DMSO 4 mg/mL (7.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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