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Cell Cycle

产品 101 到 150 共 257个

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  1. NSC 663284
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    NSC 663284

    Catalog No. A13524
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    Cdc25 抑制剂
    NSC 663284是所有Cdc25同工型的有效，细胞可渗透且不可逆的抑制剂，首选Cdc25A（对于Cdc25A，Cdc25B2和Cdc25C，IC50分别为29、95和89 nM）。 了解更多
  2. CDK9 inhibitor 2
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    CDK9 inhibitor 2

    Catalog No. A15039
    CDK9 抑制剂
    CDK9 inhibitor 2 是一种新型的细胞周期蛋白依赖性激酶9（CDK9）抑制剂。 了解更多
  3. AT7519 trifluoroacetate
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    AT7519 trifluoroacetate

    Catalog No. A15005
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    CDK 抑制剂
    AT7519 trifluoroacetate是CDK1、2、4、6和9的多CDK抑制剂，IC50为10-210 nM，对CDK3的效力较低，对CDK7的活性较低。 了解更多
  4. NG52
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    NG52

    Catalog No. A12494
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    Cell cycle-regulating kinase 抑制剂
    NG52 (Compound 52)是细胞周期调节激酶Cdc28p（IC50 = 7 μM）和相关Pho85p激酶（IC50 = 2 μM）的有效，可渗透细胞，可逆，选择性和ATP兼容的抑制剂。 了解更多
  5. LY2857785
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    LY2857785

    Catalog No. A15823
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    CDK9 抑制剂
    LY2857785是一种有效的选择性CDK9抑制剂。显着降低RNA聚合酶II CTD的磷酸化并显着降低MCL1蛋白水平，从而导致多种白血病和实体瘤细胞系发生凋亡。 了解更多
  6. RGB-286638
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    RGB-286638

    Catalog No. A13130
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    CDK 抑制剂
    RGB-286638是一种新型CDK抑制剂，对于细胞周期蛋白T1-CDK9/细胞周期蛋白B1-CDK1/细胞周期蛋白E-CDK2/细胞周期蛋白D1-CDK4/细胞周期蛋白E-CDK3的IC50为1 nM/2 nM/3 nM/4 nM/5 nM/p35-CDK5分别；对细胞周期蛋白H-CDK7和细胞周期蛋白D3-CDK6的效力较低。 了解更多
  7. ON123300
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    ON123300

    Catalog No. A12584
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    CDK4 抑制剂?
    ON123300是一种有效的多激酶抑制剂，对CDK4, Ark5, PDGFRβ, FGFR1, RET, Fyn的IC50分别为3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM和11nM，可能对脑肿瘤化学治疗有用。ON123300强烈抑制Ark5和CDK4，以及生长因子受体酪氨酸激酶，如β-型血小板衍生的生长因子受体（PDGFRβ）。 了解更多
  8. K03861
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    K03861

    Catalog No. A15889
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    CDK 抑制剂
    K03861是II型CDK2抑制剂，其CDK2（WT），CDK2（C118L），CDK2（A144C）和CDK2（C118L/A144C）的Kd分别为50 nM，18.6 nM，15.4 nM和9.7 nM。 了解更多
  9. Bohemine
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    Bohemine

    Catalog No. A15942
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    CDK 抑制剂
    Bohemine是一种有效且选择性的，细胞可渗透的，细胞周期蛋白依赖性激酶（CDK）抑制剂，IC50 = 1，M。 了解更多
  10. LY-3177833
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    LY-3177833

    Catalog No. A16325
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    CDC7 抑制剂
    LY-3177833是CDC7（细胞分裂循环7相关蛋白激酶）的有效和选择性抑制剂。 了解更多
  11. LY2835219 methanesulfonate
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    LY2835219 methanesulfonate

    Catalog No. A16386
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    CDK4/6 抑制剂
    LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。 了解更多
  12. SB1317 (TG02)
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    SB1317 (TG02)

    Catalog No. A13454
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    CDK/JAK2/FLT3 抑制剂
    SB1317是细胞周期蛋白依赖性激酶（CDKs）、类FMS酪氨酸激酶-3（FLT3）和Janus激酶2（JAK2）的有效抑制剂，CDK2、JAK2和FLT3的IC50值分别为13nM、56nM和73nM。 了解更多
  13. Atuveciclib (BAY-1143572)
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    Atuveciclib (BAY-1143572)

    Catalog No. A16810
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    Selective PTEFb/CDK9 抑制剂
    Atuveciclib (BAY-1143572)是目前处于I期的PTEFb/CDK9的高度选择性，有效且可口服的抑制剂。 了解更多
  14. ICEC0942 HCl
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    ICEC0942 HCl

    Catalog No. A16903
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    CDK7 抑制剂
    ICEC0942 HCl，也称为CT7001，是CDK7的口服生物利用选择性抑制剂。它选择性抑制CDK7，IC50为40nM。CDK1，CDK2，CDK5和CDK9的IC50值分别高45倍，15倍，230倍和30倍。 了解更多
  15. PF-06873600
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    PF-06873600

    Catalog No. A16875
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    CDK 抑制剂
    PF-06873600是一种口服生物利用型，细胞周期蛋白依赖性激酶（CDK）抑制剂，其对 CDK2、CDK4和CDK6的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM。具有潜在的抗肿瘤活性。 了解更多
  16. SEL120-34A
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    SEL120-34A

    Catalog No. A17086
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    CDK8 抑制剂
    SEL120-34A是一种有效且选择性的CDK8抑制剂，在AML细胞中具有高水平的STAT1和STAT5反式激活域丝氨酸磷酸化活性。 了解更多
  17. Trilaciclib
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    Trilaciclib

    Catalog No. A17084
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    CDK4/6 抑制剂
    Trilaciclib是潜在的一流的短效CDK4/6抑制剂，正在开发中，可在化学疗法中保存造血干细胞并增强免疫系统功能。 了解更多
  18. THZ531
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    THZ531

    Catalog No. A17036
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    CDK12 and CDK13 covalent 抑制剂
    THZ531是CDK12和CDK13共价抑制剂。THZ531不可逆地靶向位于激酶结构域外部的半胱氨酸。THZ531导致基因表达缺失，同时延伸和过度磷酸化RNA聚合酶II缺失。 了解更多
  19. BAY-1251152
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    BAY-1251152

    Catalog No. A17029
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    CDK9 抑制剂
    BAY-1251152，也称为(+)-BAY-1251152，是CDK9抑制剂。 了解更多
  20. NVP-2
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    NVP-2

    Catalog No. A17022
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    CDK9 抑制剂
    NVP-2是一种有效的选择性ATP竞争性CDK9抑制剂，IC50值为0.5 nM。 了解更多
  21. AZD4573
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    AZD4573

    Catalog No. A18321
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    CDK9 inhibitor
    AZD4573 is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. 了解更多
  22. Lerociclib (G1T38)
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    Lerociclib (G1T38)

    Catalog No. A18320
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    CDK inhibitor
    Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多
  23. MC180295
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    MC180295

    Catalog No. A18892
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    CDK9 inhibitor
    MC180295 is a highly selective CDK9 inhibitor (IC50 = 5 nM). MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect. 了解更多
  24. BI-1347
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    BI-1347

    Catalog No. A18769
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    CDK8 inhibitor
    BI-1347 is a selective inhibitor of CDK8/cyclin C with an IC50 of 1.1 nM. 了解更多
  25. CDK4/6-IN-2
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    CDK4/6-IN-2

    Catalog No. A18657
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    CDK4/CDK6 inhibitor
    CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively. 了解更多
  26. bio-THZ1
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    bio-THZ1

    Catalog No. A18559
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    covalent CDK7 inhibitor
    bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. 了解更多
  27. SY-1365
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    SY-1365

    Catalog No. A18482
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    CDK7 inhibitor
    SY-1365 is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. 了解更多
  28. THAL-SNS-032
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    THAL-SNS-032

    Catalog No. A19088
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    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
  29. FMF-04-159-2
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    FMF-04-159-2

    Catalog No. A18911
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    CDK14 inhibitor
    FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. 了解更多
  30. CDK2-IN-4
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    CDK2-IN-4

    Catalog No. A18667
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    CDK2 inhibitor
    CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM). 了解更多
  31. Abemaciclib Metabolites M2
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    Abemaciclib Metabolites M2

    Catalog No. A18416
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    CDK4/CDK6 inhibitor
    Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多
  32. MSC2530818
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    MSC2530818

    Catalog No. A12644
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    CDK8 inhibitor
    MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. 了解更多
  33. FN-1501
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    FN-1501

    Catalog No. A13559
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    FLT3/CDK inhibitor
    FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. 了解更多
  34. Ca2+ channel agonist 1
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    Ca2+ channel agonist 1

    Catalog No. A12186
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    Ca2+ channel agonist/CDK2 inhibitor
    Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction. 了解更多
  35. MLN8237 (Alisertib)
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    MLN8237 (Alisertib)

    Catalog No. A10004
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    Aurora A Kinase 抑制剂
    MLN8237 (Alisertib)是一种选择性Aurora A抑制剂，在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。 了解更多
  36. AZD1152-HQPA (Barasertib)
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    AZD1152-HQPA (Barasertib)

    Catalog No. A10109
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    Aurora Kinase B 抑制剂
    AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂，Ki值分别为0.36（Aurora B）和1369 nM（Aurora A），与一组其他50种激酶相比具有很高的特异性。 了解更多
  37. VX-680 (MK-0457, Tozasertib)
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    VX-680 (MK-0457, Tozasertib)

    Catalog No. A10981
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    Aurora Kinase 抑制剂
    VX-680 (MK-0457,Tozasertib)是一种有效的选择性Aurora激酶小分子抑制剂。 了解更多
  38. AT9283
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    AT9283

    Catalog No. A10095
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    Aurora/JAK 抑制剂
    AT9283抑制极光激酶A和B，并靶向与骨髓细胞增殖相关的其他酪氨酸和丝氨酸/苏氨酸激酶。 了解更多
  39. AMG 900
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    AMG 900

    Catalog No. A11066
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    Aurora Kinase 抑制剂
    AMG 900是一种新型有效且高度选择性的泛Aurora激酶抑制剂，在紫杉烷抗性肿瘤细胞系中具有活性。 了解更多
  40. BI-847325
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    BI-847325

    Catalog No. A15762
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    MEK/Aurora 抑制剂
    BI-847325是一种生物利用型选择性MEK/Aurora双重激酶抑制剂，对于非洲爪蟾Aurora B，人Aurora A和Aurora C以及IC50分别为3 nM，25 nM，15 nM，25 nM和4 nM IC50人MEK1和MEK2。 了解更多
  41. MK-5108 (VX-689)
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    MK-5108 (VX-689)

    Catalog No. A11410
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    Aurora A Kinase 抑制剂
    MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。 了解更多
  42. Hesperadin
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    Hesperadin

    Catalog No. A10448
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    Aurora B Kinase 抑制剂
    Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。 了解更多
  43. Danusertib (PHA-739358)
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    Danusertib (PHA-739358)

    Catalog No. A10715
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    Aurora 抑制剂
    Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力 对Lck，VEGFR2/3，c-Kit，CDK2等有效。 了解更多
  44. Reversine
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    Reversine

    Catalog No. A13250
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    human A3 adenosine receptor 拮抗剂 /Aurora 抑制剂
    Reversine是一种有效的人A3腺苷受体拮抗剂，Ki为0.66μM，是一种泛光A/B/C激酶抑制剂，IC50分别为12 nM/13 nM/20 nM。也用于干细胞去分化。 了解更多
  45. ENMD-2076
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    ENMD-2076

    Catalog No. A10352
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    Aurora A / FLT3 抑制剂
    ENMD-2076具有针对Aurora A和Flt3的选择性活性，IC50为14 nM和1.86 nM，对Aurora A的选择性是Aurora B的25倍，对VEGFR2/KDR和VEGFR3，FGFR1和FGFR2和PDGFRα的作用较小。阶段2。 了解更多
  46. KW-2449
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    KW-2449

    Catalog No. A10508
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    FLT3/FGFR/Bcr-Abl/Aurora 抑制剂
    KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。 了解更多
  47. SAR156497
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    SAR156497

    Catalog No. A14382
    Aurora Kinase 抑制剂
    SAR156497是一种选择性选择性的Aurora A，B和C抑制剂，具有体外和体内功效，IC50分别为0.5 nM（Aurora A），1 nM（Aurora B/incenp），3 nM（Aurora C/incenp）SAR156497组合具有很高的体外药效，具有令人满意的代谢稳定性，并且对CYP3A4和PDE3的抑制作用有限。 了解更多
  48. MLN8054
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    MLN8054

    Catalog No. A10601
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    Aurora A 抑制剂
    MLN8054是一种有效的，选择性Aurora A抑制剂，在Sf9昆虫细胞中IC50为4 nM，作用于Aurora A比作用于Aurora B选择性高40倍，可在体内和体外诱导人肿瘤细胞衰老。 了解更多
  49. TAK-901
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    TAK-901

    Catalog No. A11067
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    Aurora Kinase A/B 抑制剂
    TAK-901是一种新型Aurora A/B抑制剂，IC50为21 nM/15 nM。它不是细胞JAK2，c-Src或Abl的有效抑制剂。 了解更多
  50. CCT137690
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    CCT137690

    Catalog No. A11081
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    Aurora Kinase 抑制剂
    CCT137690是Aurora A，Aurora B和Aurora C的高度选择性抑制剂，IC50为15 nM，25 nM和19 nM。它对hERG离子通道影响很小。 了解更多

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  1. Chk (38)
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  3. Aurora Kinase (37)
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  5. ROCK (33)
  6. c-Myc (5)
  7. Wee1 (2)
  8. Ras (38)
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  10. G-quadruplex (3)
  11. RAD51 (3)
作用机制
  1. Inhibitor (抑制剂) (250)
  2. Agonist (激动剂) (1)
  3. Antagonist (拮抗剂) (1)
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靶点
  1. A3 adenosine receptor (1)
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  5. Aurora C (11)
  6. Bcr-Abl (1)
  7. CDK (3)
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  27. TrkA (2)
  28. VEGFR2 (FLK1) (2)
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