Cobicistat (GS-9350)

Name: Cobicistat (GS-9350)
SKU: A11277

目录号: A11277

CYP3A 抑制剂

Cobicistat (GS-9350) Chemical Structure

CAS NO. 1004316-88-4

Cobicistat (GS-9350)是有效，选择性的细胞色素酶P450 3A (CYP3A)抑制剂，包括重要的cyp3a4亚型。它还抑制肠道转运蛋白，增加几种hiv药物的整体吸收，包括atazanavir、darunavir和tenofovir alafenamide延胡索酸盐。

库存：现货

规格	价格	数量
2 mg	￥ 800.00
5 mg	￥ 1,000.00
10 mg	￥ 1,350.00
25 mg	￥ 2,500.00
10mM * 1mL in DMSO	￥ 1,200.00

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产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

靶点信息

CYP3A
30 nM-285 nM

溶解度 *

In vitro (25°C)	DMSO	85 mg/mL (109.53 mM)
	Water	Insoluble
	Ethanol	85 mg/mL (109.53 mM)
In vivo	5% DMSO+40% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.05 mL	65.27 mL	130.55 mL
0.5 mM	2.61 mL	13.05 mL	26.11 mL
1 mM	1.31 mL	6.53 mL	13.05 mL
5 mM	0.26 mL	1.31 mL	2.61 mL

*The above data is based on the productmolecular weight 766.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11277
作用机制	Inhibitor (抑制剂)
M. Wt	766.0
Formula	C40H53N7O5S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1004316-88-4
Synonyms	GS9350
SMILES	CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5