产品详情

生物活性

CPI-360是一种有效的，选择性的且具有SAM竞争性的EZH2抑制剂，IC50为102.3 nM，选择性是其他甲基转移酶的100倍以上。

靶点信息

EZH2
0.25 nM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 18 mg/mL (41.14 mM)
	Water	Insoluble
	Ethanol	Warmed: 16 mg/mL (36.57 mM)
In vivo	10% DMSO+60% PEG 400+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.86 mL	114.28 mL	228.56 mL
0.5 mM	4.57 mL	22.86 mL	45.71 mL
1 mM	2.29 mL	11.43 mL	22.86 mL
5 mM	0.46 mL	2.29 mL	4.57 mL

*The above data is based on the productmolecular weight 437.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15908
作用机制	Inhibitor (抑制剂)
M. Wt	437.53
Formula	C25H31N3O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1802175-06-9
Synonyms	CPI360, CPI 360
SMILES	CC(N1)=CC(OC)=C(CNC(C2=C(C)N([C@H](C)C3CCOCC3)C4=C2C=CC=C4)=O)C1=O