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CUDC-907 (Fimepinostat)

CUDC-907 (Fimepinostat)

Name: CUDC-907 (Fimepinostat)
SKU: A11153

目录号: A11153

PI3K/HDAC 抑制剂

Product Citations (1)

CUDC-907 (Fimepinostat) Chemical Structure

CAS NO. 1339928-25-4

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。

库存：现货

规格	价格	数量
5 mg	￥ 1,250.00
10 mg	￥ 1,750.00
50 mg	￥ 4,700.00
100 mg	￥ 9,000.00
10mM * 1mL in DMSO	￥ 1,500.00

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生物活性

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。

Targets

Target	Value
HDAC1	IC50: 1.7nM
HDAC3	IC50: 1.8nM
HDAC10	IC50: 2.8nM
HDAC2	IC50: 5.0nM
HDAC11	IC50: 5.4nM
PI3Kα	IC50: 19nM
HDAC6	IC50: 27nM
PI3Kδ	IC50: 39nM
PI3Kβ	IC50: 54nM
HDAC8	IC50: 191nM
PI3Kγ	IC50: 311nM
HDAC4	IC50: 409nM
HDAC7	IC50: 426nM
HDAC9	IC50: 554nM
HDAC5	IC50: 674nM

溶解度 *

In vitro	DMSO	87 mg/mL (171.07 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.66 mL	98.31 mL	196.62 mL
0.5 mM	3.93 mL	19.66 mL	39.32 mL
1 mM	1.97 mL	9.83 mL	19.66 mL
5 mM	0.39 mL	1.97 mL	3.93 mL

*The above data is based on the productmolecular weight 508.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11153
作用机制	Inhibitor (抑制剂)
M. Wt	508.6
Formula	C23H24N8O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1339928-25-4
Synonyms	CUDC907
SMILES	CN(CC1=CC2=C(S1)C(=NC(=N2)C3=CN=C(C=C3)OC)N4CCOCC4)C5=NC=C(C=N5)C(=O)NO