COX

Catalog No.Inhibitor Name COXCOX-1COX-2Other
A10193Celecoxib
****
A10461Ibuprofen
*
*
A10474Indomethacin
**
*
A11918Rofecoxib
****
A10304Diclofenac Sodium
***
***
A11695Lornoxicam
****
****
A10623Naproxen Sodium
*
*
A13342Valdecoxib
****
A11693Tolfenamic Acid
***
A16399Amfenac Sodium Monohydrate
**
***
A11694Nimesulide
*
A12520Meclofenamate Sodium
****
***
A16428Carprofen
****
A10636Nepafenac
A10878Sulindac
A10565Meloxicam
A10820Aspirin
A11906Phenacetin
A10736Piroxicam
A10462Ibuprofen Lysine
A11641Pranoprofen
A10090Asaraldehyde
A11692Acemetacin
A13244Bromfenac Sodium

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 64个

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  1. (S)-(+)-Flurbiprofen

    Catalog No. A12434
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    COX 抑制剂
    (S)-(+)-Flurbiprofen是一种非选择性的Cox-1和Cox-2抑制剂。 了解更多
  2. NS-398

    Catalog No. A13116
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    COX-2 抑制剂?
    NS-398是具有镇痛和解热作用的非甾体类抗炎药,可选择性抑制前列腺素G / H合酶2 /环氧合酶2(COX-2)活性,IC50为3.8μM,对COX无影响 了解更多
  3. Bromfenac sodium

    Catalog No. A13244
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    COX-2 抑制剂
    Bromfenac sodium是一种局部选择性环氧合酶(COX)-2抑制剂 了解更多
  4. Acetaminophen

    Catalog No. A10030
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    COX 抑制剂
    Acetaminophen (paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂,IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。它是广泛使用的解热和止痛药。 了解更多
  5. Naproxen sodium

    Catalog No. A10623
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    COX 抑制剂
    Naproxen sodium是一种非选择性的环氧合酶(COX)抑制剂,具有抗炎,解热和镇痛作用。对秋水仙碱引起的认知障碍和氧化应激具有神经保护作用。 了解更多
  6. FK 3311

    Catalog No. A13332
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    COX-2 抑制剂
    FK3311是一种可渗透细胞且可口服的磺酰苯胺,可作为选择性COX-2抑制剂和NSAID。 了解更多
  7. Valdecoxib

    Catalog No. A13342
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    COX-2 抑制剂
    伐地考昔(Valdecoxib),也称为SC-65872,是一种非甾体类抗炎药(NSAID),用于治疗骨关节炎,类风湿性关节炎以及痛经和月经症状。 它是一种选择性的环氧合酶2(COX-2)抑制剂,IC50为5nM。 了解更多
  8. Parecoxib

    Catalog No. A13572
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    COX-2 抑制剂
    Parecoxib是一种有效的选择性COX-2抑制剂。 了解更多
  9. Fenbufen

    Catalog No. A16002
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    Fenbufen是一种具有消炎,镇痛和解热活性的口服活性苯基链烷酸衍生物。 了解更多
  10. Diflunisal

    Catalog No. A16166
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    COX 抑制剂
    Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。 了解更多
  11. Amfenac Sodium Monohydrate

    Catalog No. A16399
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    COX 抑制剂
    Amfenac Sodium Monohydrate是一种非甾体止痛消炎药,带有乙酸部分。COX1和COX2的IC50值分别为250 nM和150 nM。 了解更多
  12. Ampiroxicam

    Catalog No. A16409
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    COX 抑制剂
    Ampiroxicam是一种非选择性的环氧合酶抑制剂,被用作抗炎药。 了解更多
  13. Carprofen

    Catalog No. A16428
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    COX-2 抑制剂
    Carprofen通过抑制COX-2和其他炎症性前列腺素来减轻炎症,不干扰COX-1活性。 了解更多
  14. Timegadine

    Catalog No. A17108
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    COX and lipo-oxygenase 抑制剂
    Timegadine被发现是一种有效的竞争性环加氧酶(COX)和脂加氧酶抑制剂,IC50的范围从5 nM(洗兔血小板)到20μM(大鼠脑)。在马血小板匀浆的细胞溶质级分和洗涤过的兔血小板中,脂氧化酶的浓度为100μM和100μM。 了解更多
  15. Ketorolac

    Catalog No. A17248
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    COX 抑制剂
    Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. 了解更多
    • 最新产品

    Firocoxib

    Catalog No. A17245
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    COX-2 抑制剂
    Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. 了解更多
  16. Aceclofenac

    Catalog No. A17433
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    COX-2 抑制剂
    Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. 了解更多
  17. Naproxen

    Catalog No. A17550
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    COX 抑制剂
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  18. Imrecoxib

    Catalog No. A18027
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    COX-2 抑制剂
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. 了解更多
  19. Deracoxib

    Catalog No. A18077
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    NSAID and COX-2 抑制剂
    Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. 了解更多
  20. Bromfenac sodium hydrate

    Catalog No. A18194
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    COX-2 抑制剂
    Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2). 了解更多
  21. Metamizole sodium hydrate

    Catalog No. A18270
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    COX 抑制剂
    Dipyrone, also known as Anador and NSC-73205, is a nonsteroidal anti-inflammatory drug used to treat pain (postoperative, colic, cancer, and migraine). 了解更多
  22. Ibuprofen (Advil)

    Catalog No. A10461
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    COX-1 抑制剂
    Ibuprofen (Advil)是一种非甾体抗炎药(NSAID),靶向COX-1,IC50为13 μM。 了解更多
  23. Ibuprofen Lysine (NeoProfen)

    Catalog No. A10462
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    COX-1 抑制剂
    Ibuprofen Lysine(Motrin)是一种非甾体抗炎药。 了解更多
  24. Asaraldehyde (Asaronaldehyde)

    Catalog No. A10090
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    COX-2 抑制剂
    Asaraldehyde (Asaronaldehyde)是一种选择性的COX-2抑制剂。 了解更多
  25. Celecoxib

    Catalog No. A10193
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    COX-2 抑制剂
    Celecoxib是一种磺胺类非甾体抗炎药(NSAID)和选择性COX-2抑制剂,在Sf9细胞中IC50为40 nM。 了解更多
  26. Pravadoline (WIN 48098)

    Catalog No. A10749
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    COX 抑制剂
    Pravadoline (WIN 48098)是抗炎和前列腺素合成抑制剂,通过抑制环氧合酶(COX)发挥作用。 了解更多
  27. Sulindac (Clinoril)

    Catalog No. A10878
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    COX 抑制剂
    Sulindac (Clinoril) 是一种非甾体类COX抑制剂,可有效抑制前列腺素的合成。 了解更多
  28. Flunixin meglumine

    Catalog No. A11686
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    COX 抑制剂
    Flunixin Meglumin是一种有效的环氧化酶(COX)抑制剂,用作止痛剂,具有抗炎和解热作用。 了解更多
  29. Acemetacin (Emflex)

    Catalog No. A11692
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    COX 抑制剂
    Acemetacin (Emflex)是一种非甾体类抗炎药,是吲哚美辛的乙醇酸酯,是一种环加氧酶抑制剂。 了解更多
  30. Tolfenamic acid

    Catalog No. A11693
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    COX-2 抑制剂
    Tolfenamic Acid是一种COX-2抑制剂,IC50为0.2μM。它是非甾体抗炎药(NSAID)的一类。它用于治疗偏头痛的症状。 了解更多
  31. Nimesulide

    Catalog No. A11694
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    COX-2 抑制剂
    Nimesulide是一种具有镇痛和解热特性的相对COX-2选择性,非甾体抗炎药(NSAID)。 了解更多
  32. Lornoxicam (Xefo)

    Catalog No. A11695
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    COX 抑制剂
    Lornoxicam (Xefo)是一种非甾体类COX-1/COX-2抑制剂。它是oxicam类的非甾体类抗炎药(NSAID),具有镇痛(缓解疼痛),抗炎和退烧(退烧)特性。 了解更多
  33. Licofelone

    Catalog No. A11697
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    COX/LOX 抑制剂
    Licofelone是一种COX/LOX双重抑制剂,被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX(环氧合酶)的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。 了解更多
  34. Diclofenac sodium

    Catalog No. A10304
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    COX 抑制剂
    Diclofenac Sodium是一种非选择性的COX抑制剂,完整细胞中的COX-1和-2的IC50分别为0.5μg/ml和0.5μg/ml,作用于绵羊COX-1和COX-2, IC50分别为60和220 nM,用作非甾体类抗炎药(NSAID)来减轻疼痛和减轻疼痛 肿胀发炎。 了解更多
  35. ATB-337

    Catalog No. A11986
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    ATB-337是H2S供体和NSAID双氯芬酸的杂合分子。 了解更多
  36. Iguratimod (T 614)

    Catalog No. A11464
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    COX-2 抑制剂
    Iguratimod (T 614)是一种抗风湿剂,能够有效地抑制COX-2的活性,IC50值为20 μM (7.7 μg/mL),而对 COX-1 无作用;Iguratimod同时为巨噬细胞移动抑制因子 (MIF) 抑制剂,IC50值为6.81 μM。 了解更多
  37. Jaceosidin

    Catalog No. A12080
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    Jaceosidin是一种来源于艾蒿的药理活性黄酮,通过阻断培养的人乳腺上皮细胞中erk-1和-2的磷酸化来抑制佛波酯诱导的cox-2和MMP-9的上调。 了解更多
  38. Piroxicam (Feldene)

    Catalog No. A10736
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    COX 抑制剂
    Piroxicam (Feldene)是前列腺素合成的有效抑制剂,并且是Cox-1和Cox-2抑制剂。 了解更多
  39. Phenylbutazone (Butazolidin, Butatron)

    Catalog No. A10720
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    COX 抑制剂
    Phenylbutazone (Butazolidin,Butatron)是一种具有研究意义的化合物,它是一种抗炎和抗增殖剂。 了解更多
  40. Indomethacin (Indocid, Indocin)

    Catalog No. A10474
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    COX 抑制剂
    Indomethacin (Indocid, Indocin)是一种非选择性COX1和COX2抑制剂,IC50分别为0.1 μg/mL和5 μg/mL。吲哚美辛(吲哚满,吲哚满)是一种非甾体抗炎药,通常用于减轻发热、疼痛、僵硬和肿胀。 了解更多
  41. Phenacetin

    Catalog No. A11906
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    Phenacetin是一种非阿片类镇痛药,无抗炎特性。 了解更多
  42. Rofecoxib (Vioxx)

    Catalog No. A11918
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    COX-2 抑制剂
    Rofecoxib (Vioxx)是一种COX-2抑制剂,IC50值为18 nM。 了解更多
  43. Tenidap

    Catalog No. A13340
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    COX-1 inhibitor
    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively. 了解更多
  44. GW-406381

    Catalog No. A19118
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    COX-2 inhibitor
    GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. 了解更多
  45. Eicosatetraynoic acid

    Catalog No. A19008
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    COX/LOX inhibitor
    Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively). Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 ?M?? 了解更多
  46. Etodolac (AY-24236)

    Catalog No. A10371
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    COX inhibitor
    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM). 了解更多
  47. Aspirin

    Catalog No. A11797
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    COX-1/COX-2 inhibitor
    Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL. 了解更多
  48. Naproxen etemesil

    Catalog No. A13052
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    COX-1 and COX-2 inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  49. Diclofenac diethylamine

    Catalog No. A16503
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    COX inhibitor
    Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor. 了解更多

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