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Cysteine protease

Inhibitory Selectivity
Catalog No.Inhibitor Name Cysteine ProteaseOther
A11265Odanacatib (MK-0822)
****
A13257E-64
***
A14245PD 151746
*
A15295Calpeptin
**
A11466Cathepsin Inhibitor 1
***
A11901PMSF
chymotrypsin
A13259Aloxistatin
A13258Loxistatin Acid (E-64C)
A14145Leupeptin Hemisulfate
serine protease
A14284Z-FA-FMK
A14220MG-101 (ALLN)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A12020 SALE

Balicatib

Cathepsin K 抑制剂
Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys.
A16381

Z-FA-FMK

Cysteine protease 抑制剂
Z-FA-FMK is an irreversible inhibitor of cysteine protease
A11466

Cathepsin Inhibitor 1

Cathepsin 抑制剂
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
A15306 SALE

PD 150606

Non-peptide calpain 抑制剂
PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.
A15303

MDL 28170

Calpain 抑制剂 III
MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.
A15295 SALE

Calpeptin

Calpain 抑制剂
Calpeptin is a cell permeable calpain inhibitor.
A15290

Acetyl-Calpastatin (184-210) (human)

Selective calpain 抑制剂
Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid ??-protein (A??) 42, A??40 and A??42 ratio.
A14911

Calpain Inhibitor II, ALLM

Calpain 抑制剂
Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain I, calpain II, cathepsin L and cathepsin B with Ki values of 120 nM, 230 nM, 0.6 nM and 100 nM, respectively.
A13640

SJA6017

reversible Calpain 抑制剂
SJA6017 is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor.
A14284

Z-FA-FMK

Irreversible Cysteine Protease 抑制剂
Z-FA-FMK is an irreversible cysteine protease inhibitor.
A14245

PD 151746

Calpain 抑制剂
PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain.
A14220

MG-101

Cysteine Protease 抑制剂
MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
A13593 SALE

CA-074 Methyl Ester

Cathepsin B 抑制剂
CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
A13502

Z-FL-COCHO

Cathepsin S 抑制剂
Z-FL-COCHO is a novel Cathepsin S inhibitor.
A15302 SALE

L 006235

Cathepsin K 抑制剂
L006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S.
A15313

SID 26681509

Human cathepsin L 抑制剂
SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G.
A13611

Gly-Phe-beta-naphthylamide

cathepsin C substrate
Gly-Phe-beta-naphthylamide is a cathepsin C substrate. The compound is described to accumulate inside lysosomes leading to their destruction.
A13257 SALE

E-64

Cysteine Protease 抑制剂
E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.
A13258

Loxistatin Acid (E64-C)

Cysteine Protease 抑制剂
Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
A14145

Leupeptin hemisulfate

Cysteine Protease 抑制剂
Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain.
A13259 SALE

E 64d (Aloxistatin)

Cysteine Protease 抑制剂
E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.
A13256

CA-074

Cathepsin B 抑制剂
A11265 SALE

Odanacatib (MK-0822)

Cathepsin K 抑制剂
Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption.
A11901

PMSF

Serine/cysteine protease 抑制剂
PMSF is an irreversible serine/cysteine protease inhibitor.

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