Danusertib (PHA-739358)

Name: Danusertib (PHA-739358)
SKU: A10715

目录号: A10715

Aurora 抑制剂

Product Citations (1)

Danusertib (PHA-739358) Chemical Structure

CAS NO. 827318-97-8

Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力对Lck，VEGFR2/3，c-Kit，CDK2等有效。

库存：现货

规格	价格	数量
5 mg	￥ 1,000.00
10 mg	￥ 1,800.00
25 mg	￥ 3,500.00
50 mg	￥ 5,600.00
10mM * 1mL in DMSO	￥ 1,200.00

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产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

Targets

Target	Value
AuroraA	IC50: 13nM
Abl	IC50: 25nM
RET	IC50: 31nM
TrkA	IC50: 31nM
FGFR1	IC50: 47nM
AuroraC	IC50: 61nM
AuroraB	IC50: 79nM

溶解度 *

In vitro (25°C)	DMSO	93 mg/mL (195.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.07 mL	105.35 mL	210.7 mL
0.5 mM	4.21 mL	21.07 mL	42.14 mL
1 mM	2.11 mL	10.54 mL	21.07 mL
5 mM	0.42 mL	2.11 mL	4.21 mL

*The above data is based on the productmolecular weight 474.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10715
作用机制	Inhibitor (抑制剂)
M. Wt	474.6
Formula	C26H30N6O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	827318-97-8
Synonyms	PHA739358
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)C(=O)NC3=NNC4=C3CN(C4)C(=O)[C@@H](C5=CC=CC=C5)OC