Dapagliflozin (BMS512148)

Name: Dapagliflozin (BMS512148)
SKU: A10285

目录号: A10285

SGLT2 抑制剂

Product Citations (5)

Dapagliflozin (BMS512148) Chemical Structure

CAS NO. 461432-26-8

Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白（SGLT2）的亚型2，后者负责肾脏中至少90％的葡萄糖重吸收。

库存：现货

规格	价格	数量
5 mg	￥ 400.00
10 mg	￥ 600.00
50 mg	￥ 1,000.00
100 mg	￥ 1,250.00
10mM * 1mL in DMSO	￥ 800.00

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生物活性

Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白（SGLT2）的亚型2，后者负责肾脏中至少90％的葡萄糖重吸收。

溶解度 *

In vitro (25°C)	DMSO	75 mg/mL (183.43 mM)
	Water	Insoluble
	Ethanol	15 mg/mL (36.68 mM)
In vivo	5% DMSO+40%PEG300+5% tween80+50% H2O	3.8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.46 mL	122.28 mL	244.56 mL
0.5 mM	4.89 mL	24.46 mL	48.91 mL
1 mM	2.45 mL	12.23 mL	24.46 mL
5 mM	0.49 mL	2.45 mL	4.89 mL

*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10285
作用机制	Inhibitor (抑制剂)
M. Wt	408.9
Formula	C21H25ClO6
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	461432-26-8
Synonyms	BMS512148, BMS-512148
SMILES	CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl