Bendamustine HCl (SDX-105)
Catalog No. A10124
Bendamustine Hydrochloride (SDX-105)是一种小分子双功能DNA烷基化剂,结合了氮芥菜碱功能和嘌呤类似物结构。苯达莫司汀具有致密的破坏DNA的功能,使其与用作抗增殖剂的其他化合物区分开来,这些功能被认为可通过多种不同途径(包括凋亡和有丝分裂灾难)促进细胞死亡。
Catalog Num | A10124 |
---|---|
M. Wt | 394.7 |
Formula | C16H21Cl2N3O2.HCl |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 3543-75-7 |
Synonyms | Ribomustin, Treanda, SDX-105, Treakisym |
SMILES | CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl |
Bendamustine Hydrochloride (SDX-105)是一种小分子双功能DNA烷基化剂,结合了氮芥菜碱功能和嘌呤类似物结构。苯达莫司汀具有致密的破坏DNA的功能,使其与用作抗增殖剂的其他化合物区分开来,这些功能被认为可通过多种不同途径(包括凋亡和有丝分裂灾难)促进细胞死亡。
Targets
DNA synthesis (Cell-free assay) | ||||
In vitro (25°C) | DMSO | 69 mg/mL (174.8 mM) | |
Water | 2 mg/mL (5.06 mM) | ||
Ethanol | 15 mg/mL (37.99 mM) | ||
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.34 mL | 126.68 mL | 253.36 mL |
0.5 mM | 5.07 mL | 25.34 mL | 50.67 mL |
1 mM | 2.53 mL | 12.67 mL | 25.34 mL |
5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
*The above data is based on the productmolecular weight 394.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.