CCT137690

Catalog No. A11081

CCT137690是Aurora A,Aurora B和Aurora C的高度选择性抑制剂,IC50为15 nM,25 nM和19 nM。它对hERG离子通道影响很小。
Catalog Num A11081
M. Wt 551.5
Formula C26H31BrN8O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1095382-05-0
Synonyms CCT-137690
SMILES CC1=CC(=NO1)CN2CCN(CC2)C3=C4C(=NC=C3Br)N=C(N4)C5=CC=C(C=C5)N6CCN(CC6)C
CCT137690是Aurora A,Aurora B和Aurora C的高度选择性抑制剂,IC50为15 nM,25 nM和19 nM。它对hERG离子通道影响很小。
Targets
Aurora A Aurora C Aurora B
15 nM19 nM25 nM
In vitro (25°C) DMSO 4 mg/mL (7.25 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.13 mL 90.66 mL 181.32 mL
0.5 mM 3.63 mL 18.13 mL 36.26 mL
1 mM 1.81 mL 9.07 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL

*The above data is based on the productmolecular weight 551.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.