Citarinostat (ACY-241)

Catalog No. A12758

ACY-241是HDAC6的新型，选择性和口服抑制剂。对HDAC6和HDAC3的IC50分别为2.6 nM和46 nM。

Product Citations

Bae J, .et al. Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors, Leukemia, 2018, Sep;32(9):1932-1947 PMID: 29487385

Technical details

Catalog Num	A12758
M. Wt	467.95
Formula	C24H26ClN5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1316215-12-9
Synonyms	HDAC-IN-2
SMILES	ClC1=CC=CC=C1N(C2=CC=CC=C2)C3=NC=C(C=N3)C(NCCCCCCC(NO)=O)=O

Biological Activity

ACY-241是HDAC6的新型，选择性和口服抑制剂。对HDAC6和HDAC3的IC50分别为2.6 nM和46 nM。

Solubility *

In vitro	DMSO	39 mg/mL (83.34 mM)
	Water	Insoluble
	Ethanol	87 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.37 mL	106.85 mL	213.7 mL
0.5 mM	4.27 mL	21.37 mL	42.74 mL
1 mM	2.14 mL	10.68 mL	21.37 mL
5 mM	0.43 mL	2.14 mL	4.27 mL

*The above data is based on the productmolecular weight 467.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.