PD 151746

Catalog No. A14245

PD 151746是一种选择性的，细胞可渗透的钙蛋白酶抑制剂，对μ-钙蛋白酶的Ki值为0.26 uM，选择性是m-钙蛋白酶的20倍。

Technical details

Catalog Num	A14245
M. Wt	237.25
Formula	C11H8FNO2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	179461-52-0
Synonyms	PD-151746,PD151746
SMILES	C1=CC2=C(C=C1F)C(=CN2)/C=C(/C(=O)O)\S

Biological Activity

PD 151746是一种选择性的，细胞可渗透的钙蛋白酶抑制剂，对μ-钙蛋白酶的Ki值为0.26 uM，选择性是m-钙蛋白酶的20倍。

Targets

μ-Calpain	m-calpain
260 nM	5.33 μM

Solubility *

In vitro	DMSO	40 mg/mL (168.6 mM)
	Water	Insoluble
	Ethanol	40 mg/mL (168.6 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	42.15 mL	210.75 mL	421.5 mL
0.5 mM	8.43 mL	42.15 mL	84.3 mL
1 mM	4.21 mL	21.07 mL	42.15 mL
5 mM	0.84 mL	4.21 mL	8.43 mL

*The above data is based on the productmolecular weight 237.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.