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ATM / ATR

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Catalog No. Product Name Application Product Information
A10133 SALE

BEZ235 (NVP-BEZ235, Dactolisib)

PI3K/mTOR 抑制剂
BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
A15842 SALE

Mirin

ATM 抑制剂
Mirin prevents ATM activation in response to double strand breaks (IC50 = 12 uM) and induces G2 cell cycle arrest.
A15794 SALE

AZD6738

ATR 抑制剂
AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
A13289 SALE

VE-822

ATR 抑制剂
VE-822 is an potent ATR inhibitor.
A13328

ETP-46464

ATR 抑制剂
ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
A13205

AZ-20

ATR kinase 抑制剂
AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM.
A13191 SALE

CGK 733

ATM/ATR 抑制剂
CGK733 is a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells.
A11586

Torin 2

mTOR 抑制剂
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
A11991

Schisandrin B

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Schisandrin B is the most abundant dibenzocyclooctadiene isolated from the fruit of Schisandra chinensis (Turcz) Baillon or Wu-Wei-Zi (transliterally meaning "the fruit of five tastes" in Chinese), which is a commonly used tonic herb in Chinese medicine, particularly for the treatment of liver ailments.
A11605 SALE

VE-821

ATM/ATR 抑制剂
VE-821 is a potent and selective inhibitor of protein kinase ATR.
A10507 SALE

KU-60019

ATM 抑制剂
KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
A11161 SALE

Wortmannin

PI3K 抑制剂

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

A11086

CP-466722

ATM 抑制剂
CP-466722 is a specific ATM inhibitor that inhibits cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects.
A10506 SALE

KU-55933

ATM 抑制剂
KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
A14136

NU6027

ATR/CDK inhibito
NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.

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