PARP

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  1. BMN-673 8R,9S

    Catalog No. A15024
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    PARP 抑制剂
    BMN-673 8R,9S 是BMN-673的(8R,9S)对映异构体。BMN 673是一种新型PARP抑制剂,IC50为0.58 nM。 了解更多
  2. PJ34

    Catalog No. A15215
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    PARP 抑制剂
    PJ34是新型有效的PARP-1/2特异性抑制剂,EC50为20 nM。 了解更多
  3. 4-HQN

    Catalog No. A15370
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    PARP 抑制剂
    4-HQN已显示抑制PARP(聚(ADP-核糖)合成酶),该酶催化NAD+的ADP-核糖部分与各种蛋白质的共价结合。 了解更多
  4. BYK 204165

    Catalog No. A15371
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    PARP-1 抑制剂
    BYK204165是一种可渗透细胞的异喹啉二酮化合物,可有效并选择性地抑制聚(ADP-核糖)聚合酶1(PARP1)。 了解更多
  5. BYK 49187

    Catalog No. A15372
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    PARP-1/PARP-2 抑制剂
    BYK 49187,PARP-1和PARP-2抑制剂(无细胞重组PARP-1和鼠PARP-2的pIC50值分别为8.36和7.50)。 了解更多
  6. DR 2313

    Catalog No. A15373
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    PARP 抑制剂
    DR 2313是一种水溶性嘧啶酮化合物,起PARP(聚(ADP-核糖)聚合酶)抑制剂的作用。 了解更多
  7. EB 47

    Catalog No. A15374
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    PARP1 抑制剂
    EB 47是PARP1的有效抑制剂,IC50为45 nM。 了解更多
  8. NU 1025

    Catalog No. A15375
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    PARP 抑制剂
    NU 1025是一种有效的聚(ADP-核糖)聚合酶(PARP)抑制剂,可增强L1210细胞中一系列机制多样的抗癌药的细胞毒性。 了解更多
  9. G007-LK

    Catalog No. A15528
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    TNKS 抑制剂
    G007-LK对坦科聚合酶1和2具有很高的选择性,生化IC50值分别为46 nM和25 nM,细胞IC50值为50 nM,并具有出色的小鼠药代动力学特征, 了解更多
  10. NVP-TNKS656

    Catalog No. A15786
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    TNKS2 抑制剂
    NVP-TNKS656是一种高效,选择性和活性的TNKS2抑制剂,IC50为6 nM。对PARP1和PARP2的选择性> 300倍。 了解更多
  11. MN-64

    Catalog No. A15927
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    TNKS 抑制剂
    MN-64是Tankyrase 1和2的有效和选择性抑制剂(IC50分别为6和72 nM)。 了解更多
  12. AZ6102

    Catalog No. A15873
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    TNKS1/2 抑制剂
    AZ6102是有效的TNKS1/2抑制剂,对其他PARP家族酶具有100倍的选择性,对DLD-1细胞中Wnt途径的抑制作用的IC50为5 nM。 了解更多
  13. BGP-15

    Catalog No. A16344
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    PARP 抑制剂
    BGP-15是一种PARP抑制剂,可以预防小鼠的心力衰竭和心房颤动。 了解更多
  14. GeA-69

    Catalog No. A19705
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    PARP14 inhibitor
    GeA-69 is a selective, highly cell permeable allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2, with a Kd of 2.1 ?M. 了解更多
  15. Talazoparib tosylate

    Catalog No. A20238
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    PARP1/2 inhibitor
    Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. 了解更多
  16. PARP-2-IN-1

    Catalog No. A20240
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    PARP-2 inhibitor
    PARP-2-IN-1 is a potent and selective PARP-2 inhibitor with an IC50 of 11.5 nM. 了解更多
  17. INO-1001

    Catalog No. A20680
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    PARP inhibitor
    INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. 了解更多
  18. AG-014699 (Rucaparib)

    Catalog No. A10045
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    PARP 抑制剂
    AG-014699 (Rucaparib)是一种PARP抑制剂,可抑制聚(ADP-核糖)聚合酶(PARP,后者是DNA修复中的关键酶。 无细胞试验中作用于PARP1的Ki为1.4 nM,对其余8个PARP位点也有结合亲和力。 了解更多
  19. AG14361

    Catalog No. A10046
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    PARP 抑制剂
    AG14361是一种有效的PARP抑制剂,可在MMR(错配修复)有效/不足的细胞中增强替莫唑胺(TMZ)的细胞毒性。 了解更多
  20. BSI-201 (Iniparib)

    Catalog No. A10164
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    PARP 抑制剂
    BSI-201 (Iniparib)是一种有效的PARP-1抑制剂,已被证明可以穿越血脑屏障。 了解更多
  21. 3-Aminobenzamide

    Catalog No. A10475
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    PARP 抑制剂
    3-Aminobenzamide是一种新型PARP抑制剂,已知它通过抑制DNA损伤的修复使细胞在体外对辐射敏感。 了解更多
  22. A-966492

    Catalog No. A10019
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    PARP1 抑制剂
    A-966492在全细胞试验中显示出对K(i)为1 nM,EC(50)为1 nM的聚(ADP-核糖)聚合酶-1(PARP-1)酶的高效力。 了解更多
  23. MK-4827 (Niraparib)

    Catalog No. A11026
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    PARP 抑制剂
    MK-4827 (Niraparib)是一种新型有效的口服生物可利用的PARP-1和PARP-2抑制剂。 了解更多
  24. BMN673

    Catalog No. A11243
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    PARP 抑制剂
    BMN-673是核酶聚(ADP-核糖)聚合酶(PARP)的口服生物利用抑制剂,无细胞试验中对PARP1的IC50为0.57 nM。它也是有效的PARP-2抑制剂,但不抑制PARG,对PTEN突变型高度敏感。具有潜在的抗肿瘤活性。 了解更多
  25. PJ 34 hydrochloride

    Catalog No. A12665
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    PARP 抑制剂
    PJ 34 hydrochloride是聚(ADP-核糖)聚合酶(PARP)(EC50 = 20 nM)的有效抑制剂。 了解更多
  26. UPF 1069

    Catalog No. A12750
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    PARP2 抑制剂
    UPF 1069是一种选择性聚(ADP-核糖)聚合酶(PARP)2抑制剂(PARP-2和PARP-1的IC50值分别为0.3和8.0μM)。 了解更多
  27. AZD-2461

    Catalog No. A12393
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    PARP 抑制剂
    AZD2461是新型有效的PARP抑制剂,对P-糖蛋白的亲和力较低。 了解更多
  28. JW 55

    Catalog No. A13731
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    TNKS1/2 抑制剂
    JW 55是端锚聚合酶1和2(TNKS1/2)的PARP域的抑制剂。 了解更多
  29. Rucaparib

    Catalog No. A14182
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    PARP-1 抑制剂
    Rucaparib是纯化的全长人PARP-1的有效抑制剂,对LoVo和SW620细胞中的细胞PARP具有更高的抑制作用。 了解更多
  30. Olaparib (AZD2281)

    Catalog No. A10111
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    PARP 抑制剂
    Olaparib (AZD2281)是聚ADP核糖聚合酶(PARP)的抑制剂,该酶是一种与DNA修复有关的酶。 了解更多
  31. ME0328

    Catalog No. A14309
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    PARP3 抑制剂
    ME0328是一种有效的选择性PARP抑制剂,对PARP3的IC50为0.89μM,选择性是PARP1的7倍。 了解更多
  32. Benzamide

    Catalog No. A14371
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    PARP-1 抑制剂
    Benzamide是苯甲酸的酰胺衍生物,是聚(ADP-核糖)聚合酶-1(PARP-1)的抑制剂。 了解更多
  33. ABT-888 (Veliparib)

    Catalog No. A10026
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    PARP 抑制剂
    ABT-888 (Veliparib)是一种潜在的抗癌药物,可作为PARP抑制剂。 了解更多
  34. NMS-P118

    Catalog No. A20994
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    PARP-1 Inhibitor
    NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy. 了解更多
  35. Veliparib dihydrochloride

    Catalog No. A21356
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    PARP inhibitor
    Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. 了解更多
  36. Niraparib R-enantiomer

    Catalog No. A21880
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    PARP1 inhibitor
    Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. 了解更多
  37. E7449

    Catalog No. A21553
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    PARP1/PARP2 inhibitor
    E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. 了解更多
  38. Niraparib hydrochloride

    Catalog No. A18018
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    PARP1 and PARP2 inhibitor
    Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多
  39. Niraparib tosylate

    Catalog No. A16618
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    PARP1/PARP2 inhibitor
    Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. 了解更多
  40. PARP14 inhibitor H10

    Catalog No. A18616
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    PARP14 抑制剂
    PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (??24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. 了解更多
  41. NMS-P515

    Catalog No. A18449
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    PARP-1 抑制剂
    NMS-P515 is a potent inhibitor of PARP-1 both in biochemical (Kd: 0.016 μM) and cellular (IC50: 0.027 μM) assays. 了解更多
  42. Rucaparib (Camsylate)

    Catalog No. A18013
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    PARP 抑制剂
    Rucaparib Camsylate is an inhibitor of PARP with a Ki of 1.4 nM for PARP1, and also shows binding affinity to eight other PARP domains. 了解更多
    • 最新产品

    XMD16-5

    Catalog No. A17130
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    TNK2 抑制剂
    XMD16-5是酪氨酸激酶非受体2(TNK2)抑制剂。 了解更多
    • 最新产品

    XMD8-87

    Catalog No. A17134
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    TNK2 抑制剂
    XMD8-87是酪氨酸激酶非受体2(TNK2)抑制剂,IC50值为1.9μM。 了解更多
  43. Lanifibranor

    Catalog No. A17041
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    PARP 激动剂
    Lanifibranor,也称为IVA-337,是一种过氧化物酶体增殖物激活受体(PPAR)激动剂。 了解更多
  44. Pamiparib

    Catalog No. A17073
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    PARP 抑制剂
    Pamiparib也称为BGB-290,是一种高效的,选择性的PARP抑制剂,具有良好的药物代谢和药代动力学特性。 了解更多
  45. TC-E 5001

    Catalog No. A11454
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    TNKS 抑制剂
    TC-E 5001是双重tankyrase(TNKS)抑制剂(TNKS1和TNKS2的Kd值分别为79和28 nM,TNKS2的IC50 = 33 nM),在PARP1和PARP2上没有活性(IC50> 19 uM)。抑制Wnt信号并稳定Axin2水平。 了解更多
  46. WIKI4

    Catalog No. A14283
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    Tankyrase 抑制剂
    WIKI4是一种新型的Tankyrase抑制剂,对TNKS2的IC50为15 nM。 了解更多
  47. AIM-100

    Catalog No. A14986
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    Ack1 (TNK2) 抑制剂
    AIM-100是Ack1的小分子抑制剂,IC50为24 nM。 了解更多

49 个项目

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