Droxinostat

目录号: A10337

HDAC 抑制剂

Droxinostat

Droxinostat Chemical Structure

CAS NO. 99873-43-5

Droxinostat是HDAC3,HDAC6和HDAC8的选择性抑制剂,显示出可比较的HDAC6和HDAC8抑制作用,IC50分别为2.47和1.46μmol/ L。

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 700.00
50 mg
¥ 3,200.00
100 mg
¥ 5,800.00
10mM * 1mL in DMSO
¥ 780.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Droxinostat是HDAC3,HDAC6和HDAC8的选择性抑制剂,显示出可比较的HDAC6和HDAC8抑制作用,IC50分别为2.47和1.46μmol/ L。
Targets
Target Value
HDAC8IC50: 1.46μM
HDAC6IC50: 2.47μM
HDAC3IC50: 16.9μM
HDAC9IC50: >20μM
HDAC10IC50: >20μM
HDAC1IC50: >20μM
HDAC2IC50: >20μM
HDAC4IC50: >20μM
HDAC5IC50: >20μM
HDAC7IC50: >20μM
In vitro (25°C) DMSO 47 mg/mL (192.86 mM)
Water Insoluble
Ethanol 47 mg/mL (192.86 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.03 mL 205.17 mL 410.34 mL
0.5 mM 8.21 mL 41.03 mL 82.07 mL
1 mM 4.1 mL 20.52 mL 41.03 mL
5 mM 0.82 mL 4.1 mL 8.21 mL

*The above data is based on the productmolecular weight 243.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10337
作用机制 Inhibitor (抑制剂)
M. Wt 243.7
Formula C11H14ClNO3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 99873-43-5
SMILES CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO

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