E3 ligase

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Catalog No. Product Name Application Product Information
A10884

TAME

APC/C 抑制剂
TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor with an IC50 of 12 μM.
A13253

SMER-3

Ubiquitin E3 Ligase 抑制剂
SMER3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation.
A13654

HLI-98C

Hdm2 ubiquitin ligase 抑制剂
HLI-98C, an analog, indeed inhibited Mdm2 E3 ligase activity.
A15347

HLI 373

HDM2 抑制剂
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription.
A15453 SALE

PRT 4165

Bmi1/Ring1A 抑制剂
PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha.
A10924

Thalidomide

E3 ubiquitin ligase 抑制剂
Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo.

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