Endothelin Receptors

21 个项目

每页

设置降序顺序
  1. Zibotentan (ZD4054)

    Catalog No. A11006
    Quick View
    ETA-receptor 拮抗剂
    Zibotentan (ZD4054)是一种有效且特异性的ETA受体(内皮素A受体)拮抗剂(IC50 = 21 nM),对ETB没有抑制活性。 了解更多
  2. Bosentan

    Catalog No. A11091
    Quick View
    ETAR/ETBR 抑制剂
    Bosentan是内皮素-1(ET-A)和内皮素B(ET-B)受体的竞争性拮抗剂。 了解更多
  3. Ambrisentan (BSF 208075)

    Catalog No. A11291
    Quick View
    EndothelinA receptor 拮抗剂
    Ambrisentan (BSF 208075)充当内皮素受体拮抗剂,对A型内皮素受体(ETA)具有选择性。 了解更多
  4. Avosentan (SPP301)

    Catalog No. A11301
    Quick View
    Endothelin 拮抗剂
    Avosentan (SPP301)是一种强效且高度选择性的ETA受体阻滞剂。 了解更多
  5. Sitaxsentan sodium (TBC-11251)

    Catalog No. A11564
    Quick View
    ETA receptor 拮抗剂
    Sitaxsentan sodium (TBC-11251)是一种选择性内皮素受体A拮抗剂,IC50和Ki分别为1.4 nM和0.43 nM。 了解更多
  6. BQ-788

    Catalog No. A14369
    Quick View
    ETBR 拮抗剂
    BQ-788 sodium salt是一种选择性ETBR(内皮素受体B)拮抗剂。 了解更多
  7. Atrasentan

    Catalog No. A13779
    Quick View
    ETA 拮抗剂
    Atrasentan是一种实验药物,正在研究中,用于治疗各种类型的癌症,包括非小细胞肺癌。它是对A型亚型(ETA)有选择性的内皮素受体拮抗剂,对ETA的IC50为0.0551 nM。 了解更多
  8. Endothelin-2, human

    Catalog No. A14894
    Quick View
    Endothelin-2, human是人的内源肽,主要存在于肾脏和肠中。对ETA和ETB内皮素受体具有相似的选择性。 了解更多
  9. Atrasentan HCl

    Catalog No. A15007
    Quick View
    Endothelin 拮抗剂 receptor
    Atrasentan hydrochloride是一种开发用于治疗前列腺癌的内皮素拮抗剂受体(IC50 = 0.0551 nM,ETA)。 了解更多
  10. BQ-123

    Catalog No. A15912
    Quick View
    ETA receptor 拮抗剂
    BQ-123是一种选择性内皮素A受体(ETA)拮抗剂,IC50为7.3 nM。 了解更多
  11. Bosentan Hydrate

    Catalog No. A14944
    Quick View
    ET-A and ET-B 拮抗剂
    Bosentan Hydrate是ET-A和ET-B的内皮素(ET)受体拮抗剂,Ki分别为4.7 nM和95 nM。 了解更多
  12. Aprocitentan

    Catalog No. A21999
    Quick View
    dual ETA/ETB antagonist
    Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. 了解更多
  13. Macitentan (n-butyl analogue)

    Catalog No. A21845
    Quick View
    endothelin ETA and ETB receptor antagonist
    Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). 了解更多
  14. Darusentan

    Catalog No. A21280
    Quick View
    endothelin A (ETA) receptor antagonist
    Darusentan is a selective endothelin A (ETA) receptor antagonist. 了解更多
  15. Tezosentan

    Catalog No. A21118
    Quick View
    endothelin (ET) receptor antagonist
    Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively. 了解更多
  16. Sparsentan

    Catalog No. A20879
    Quick View
    angiotensin II and endothelin A receptor antagonist
    Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively. 了解更多
  17. Endothelin Mordulator 1

    Catalog No. A13040
    Quick View
    endothelin receptor modulator
    Endothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders. 了解更多
  18. PD-159020

    Catalog No. A13499
    Quick View
    ETA/ETB antagonist
    PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively. 了解更多
  19. RO462005

    Catalog No. A13216
    Quick View
    endothelin receptor 激动剂
    RO462005是内皮素受体选择性激动剂。 了解更多
  20. Macitentan

    Catalog No. A11492
    Quick View
    Endothelin receptor 拮抗剂
    Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂,IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。 了解更多
  21. IRL-2500

    Catalog No. A13638
    Quick View
    ETBR 拮抗剂
    IRL-2500是一种有效的选择性ETBR拮抗剂。它显示了对ETB受体的一些选择性(对于ETB和ETA受体,IC50值分别为1.3和94 nM)。 了解更多

21 个项目

每页

设置降序顺序
Rewards