Entrectinib

目录号: A15801

TRK, ROS1, ALK 抑制剂

Entrectinib

Entrectinib Chemical Structure

CAS NO. 1108743-60-7

Entrectinib,也称为RXDX-101和NMS-E628,是TrkA,TrkB和TrkC以及ROS1和ALK的小分子抑制剂,具有很高的效力和选择性。

库存: 现货

规格 价格 数量
5 mg
¥ 550.00
10 mg
¥ 850.00
25 mg
¥ 1,600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Entrectinib,也称为RXDX-101和NMS-E628,是TrkA,TrkB和TrkC以及ROS1和ALK的小分子抑制剂,具有很高的效力和选择性。
靶点信息
TrkA TrkB TrkC ROS1 ALK
In vitro DMSO 89 mg/mL (158.74 mM)
Water Insoluble
Ethanol 67 mg/mL (119.5 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.18 mL 178.37 mL
0.5 mM 3.57 mL 17.84 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15801
作用机制 Inhibitor (抑制剂)
M. Wt 560.64
Formula C31H34F2N6O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1108743-60-7
Synonyms RXDX-101, RXDX-101, RXDX-101, NMS E628, NMS-E628, NMSE628
SMILES CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

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