ERK

Catalog No.Inhibitor Name ERK1ERK2ERK5ERKOther
A12824SCH772984
***
****
A12505VX-11e
***
GSK3,AURA,CDK2
A15802DEL-22379
*
*
A11794Ulixertinib
****
A13420GDC-0994
***
****
A14119FR 180204
*
**
A11609XMD8-92
**
A16232ERK5-IN-1
**
A11225Pluripotin (SC-1)
**
RasGAP

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

21 个项目

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  1. ERK-IN-1

    Catalog No. A19080
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    RAF/ERK1/2 inhibitor
    ERK-IN-1 (compound B) is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. 了解更多
    • 最新产品

    AG-126

    Catalog No. A17146
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    ERK2 抑制剂
    AG-126是一种ERK2抑制剂,它在25-50μM下选择性抑制ERK1(p44)和ERK2(p42)的磷酸化。 了解更多
  2. LY3214996

    Catalog No. A16843
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    ERK 抑制剂
    LY3214996是一种选择性的新型ERK1/2抑制剂,在生化分析中两种酶的IC50为5 nM。它有效抑制BRAF和RAS突变癌细胞系中的细胞磷酸RSK1。 了解更多
  3. AZD0364

    Catalog No. A16839
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    ERK 抑制剂
    AZD0364是一种临床前ERK1/2抑制剂,对ERK2的IC50为0.6 nM。 了解更多
  4. MK-8353 (SCH900353)

    Catalog No. A16838
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    ERK 抑制剂
    MK-8353 (SCH900353)是一种口服生物利用型,选择性和有效的ERK抑制剂,在体外抑制激活的ERK1和ERK2,IC50值分别为23.0 nM和8.8 nM(IMAP激酶测定),以及未激活的ERK2,具有IC50值 0.5 nM(MEK1-ERK2耦合测定)。 了解更多
  5. CC-90003

    Catalog No. A16837
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    ERK1/2 抑制剂
    CC-90003是ERK1/2的不可逆抑制剂,IC50在10-20 nM范围内,在258激酶生化分析中显示出良好的激酶选择性。 了解更多
  6. Tomatidine

    Catalog No. A16233
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    ERK/Akt/NF-kB 抑制剂
    Tomatidine抑制ERK,Akt的磷酸化以及NF-kB的核含量。具有抗炎特性。 了解更多
  7. ERK5-IN-1

    Catalog No. A16232
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    ERK5 抑制剂
    ERK5-IN-1表现出对ERK5的有效抑制,其细胞EC50值为0.19 uM,酶促IC50值为0.087 uM,LRRK2 [G2019S]具有酶促IC50值为0.026uM。 了解更多
  8. APS-2-79

    Catalog No. A16231
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    KSR/Ras 抑制剂
    APS-2-79是RAF通过直接结合KSR活性位点而使MEK磷酸化的拮抗剂。 了解更多
  9. DEL-22379

    Catalog No. A15802
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    ERK 抑制剂
    DEL-22379是一种有效的选择性ERK二聚体抑制剂,可抑制ERK二聚体而不影响ERK磷酸化,阻止由RAS-ERK途径癌基因驱动的肿瘤发生。 了解更多
  10. TMCB

    Catalog No. A13977
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    CK2/ERK8 抑制剂
    MCB抑制酪蛋白激酶2(CK2)和细胞外信号调节激酶8(ERK8/MAPK15)(CK2和ERK8的IC50 = 0.50 uM)。 了解更多
  11. XMD8-92

    Catalog No. A11609
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    BMK1/ERK5 抑制剂
    XMD8-92是一种有效的选择性BMK1/ERK5抑制剂。 了解更多
  12. XMD 17-109

    Catalog No. A14090
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    ERK5 抑制剂
    XMD17-109是一种新型的ERK-5特异性抑制剂,在HEK293细胞中的EC50值为4.2 uM。 了解更多
  13. GDC0994 (Ravoxertinib)

    Catalog No. A13420
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    ERK1/2 抑制剂
    GDC-0994是一种强效选择性Erk1/2抑制剂。GDC-0994抑制ERK磷酸化和ERK介导的信号转导通路的激活。 了解更多
  14. Ulixertinib (BVD-523, VRT752271)

    Catalog No. A11794
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    ERK1/ERK2 抑制剂
    Ulixertinib (BVD-523,VRT752271)是ERK蛋白激酶的吡咯抑制剂。 了解更多
  15. Pluripotin (SC-1)

    Catalog No. A11225
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    ERK1/RasGAP 抑制剂
    Pluripotin (SC-1)的活性是通过联合抑制RasGAP和ERK1介导的,其Kd值分别为98和212 nM。 了解更多
  16. FR 180204

    Catalog No. A14119
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    ERK 抑制剂
    FR 180204是细胞外信号调节激酶(ERK)的新型选择性抑制剂,它可能是类风湿关节炎的潜在新疗法。 了解更多
  17. TCS ERK 11e (VX-11e)

    Catalog No. A12505
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    ERK2 抑制剂
    TCS ERK 11e (VX-11e)是一种有效且选择性的细胞外信号相关激酶2(ERK2)抑制剂(ERK2,GSK-3,Aurora激酶A和Cdk2的Ki值分别<2、395、540和852 nM)。有效阻断HT29细胞的增殖(IC50 = 48 nM)。 了解更多
  18. SCH772984

    Catalog No. A12824
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    ERK 抑制剂
    SCH772984是一种新型的ERK1/2特异性抑制剂,IC50分别为4 nM和1 nM。 了解更多
  19. ERK5-IN-2

    Catalog No. A18871
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    ERK5 inhibitor
    ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. 了解更多
  20. BAY885

    Catalog No. A13765
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    ERK5 inhibitor
    BAY885 is a novel ERK5 inhibitor. 了解更多

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