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ERK5-IN-1表现出对ERK5的有效抑制，其细胞EC50值为0.19 uM，酶促IC50值为0.087 uM，LRRK2 [G2019S]具有酶促IC50值为0.026uM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.76 mL | 108.8 mL | 217.61 mL |
| 0.5 mM | 4.35 mL | 21.76 mL | 43.52 mL |
| 1 mM | 2.18 mL | 10.88 mL | 21.76 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
*The above data is based on the productmolecular weight 459.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16232 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 459.54 |
| Formula | C25H29N7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1234479-76-5 |
| Synonyms | ERK5 IN 1, ERK5IN1 |
| SMILES | O=C1N(C)C2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3OC)N=C2N(C)C5=CC=CC=C15 |
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