Everolimus (RAD001)

Name: Everolimus (RAD001)
SKU: A10374

目录号: A10374

mTOR 抑制剂

Product Citations (9)

Everolimus (RAD001) Chemical Structure

CAS NO. 159351-69-6

Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。

库存：现货

规格	价格	数量
10 mg	￥ 600.00
50 mg	￥ 1,050.00
100 mg	￥ 1,350.00
10mM * 1mL in DMSO	￥ 1,160.00

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生物活性

Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。

靶点信息

mTOR (FKBP12) (Cell-free assay)
1.6 nM-2.4 nM

溶解度 *

In vitro (25°C)	DMSO	91 mg/mL (94.97 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (6.26 mM)
In vivo	30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.44 mL	52.18 mL	104.36 mL
0.5 mM	2.09 mL	10.44 mL	20.87 mL
1 mM	1.04 mL	5.22 mL	10.44 mL
5 mM	0.21 mL	1.04 mL	2.09 mL

*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10374
作用机制	Inhibitor (抑制剂)
M. Wt	958.2
Formula	C53H83NO14
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	159351-69-6
Synonyms	SDZ-RAD, Certican, Zortress, Afinitor
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC