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Factor Xa

Inhibitory Selectivity
Catalog No.Inhibitor Name Factor XaOther
A10800Rivaroxaban
**
Prothrombinase
A10082Apixaban
****
A14317Edoxaban
***
Thrombin,FIXa

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Catalog No. Product Name Application Product Information
A10082 SALE

Apixaban (BMS-562247-01)

Factor Xa 抑制剂
Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.
A14979

5-R-Rivaroxaban

Factor Xa 抑制剂
5-R-Rivaroxaban is (R) enantiomer of Rivaroxaban. Rivaroxaban is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders.
A14317 SALE

Edoxaban

Factor Xa 抑制剂
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM
A14099

DPC-423

factor Xa 抑制剂
DPC423 is a highly potent and orally bioavailable pyrazole antithrombotic agent.
A13878 SALE

ABT333

NS5B 抑制剂
ABT333 is an NS5B non-nucleoside polymerase inhibitor.
A12518 SALE

Betrixaban

FXa 抑制剂
Betrixaban is an anticoagulant drug which acts as a direct factor Xa inhibitor. It is potent, orally active and highly selective for factor Xa, being selected from a group of similar compounds for its low hERG affinity.
A12411

Rivaroxaban Diol

-
Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.
A12871

Letaxaban (TAK-442)

factor Xa 抑制剂
Letaxaban, also known as TAK-442, is a potent, selective, and orally active factor Xa inhibitor, which is a tetrahydropyrimidin-2(1H)-one derivative. TAK-442 inhibited endogenous FXa activity in platelet-poor human [half-maximal inhibitory concentration (IC(50)): 53 nM, TAK-442] and rat (IC(50): 32 nM, TAK-442) plasma.
A12870

Razaxaban

factor Xa 抑制剂
Razaxaban is a selective, potent, and orally bioavailable inhibitor of coagulation factor Xa.
A11517

Otamixaban (FXV 673)

factor Xa 抑制剂
Otamixaban(FXV 673) is an intravenous direct factor Xa inhibitor.
A10800 SALE

Rivaroxaban (Xarelto)

Factor Xa 抑制剂
Rivaroxaban is an oxazolidinone derivative optimized for inhibiting both free Factor Xa and Factor Xa bound in the prothrombinase complex.
A10158

BMS-740808

Factor Xa 抑制剂

BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.

A15076

Edoxaban tosylate

Factor Xa 抑制剂
Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

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