Factor Xa

Catalog No.Inhibitor Name Factor XaOther
A10800Rivaroxaban
**
Prothrombinase
A10082Apixaban
****
A14317Edoxaban
***
Thrombin,FIXa

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Edoxaban tosylate

    Catalog No. A15076
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    Factor Xa 抑制剂
    Edoxaban tosylate是临床预防卒中的口服Xa(FXa)抑制剂。 了解更多
  2. 5-R-Rivaroxaban

    Catalog No. A14979
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    Factor Xa 抑制剂
    5-R-Rivaroxaban是利伐沙班的(R)对映异构体。利伐沙班是一种新型的口服直接Xa因子抑制剂,在晚期开发中用于预防和治疗血栓栓塞性疾病。 了解更多
  3. Edoxaban (tosylate Monohydrate)

    Catalog No. A14317
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    Factor Xa 抑制剂
    Edoxaban (tosylate Monohydrate)是选择性Factor Xa抑制剂,Ki为0.561 nM。 了解更多
  4. DPC-423

    Catalog No. A14099
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    factor Xa 抑制剂
    DPC423是一种高效且可口服生物利用的吡唑抗血栓形成剂。 了解更多
  5. ABT333

    Catalog No. A13878
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    NS5B 抑制剂
    ABT333是NS5B非核苷聚合酶抑制剂。 了解更多
  6. Betrixaban

    Catalog No. A12518
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    FXa 抑制剂
    Betrixaban是一种抗凝血药,可作为直接Xa因子抑制剂。它具有强大的,口服活性和对因子Xa的高度选择性,由于其低hERG亲和力而从一组相似的化合物中选择。 了解更多
  7. Rivaroxaban Diol

    Catalog No. A12411
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    Rivaroxaban Diol是恶唑烷酮衍生物,经优化可抑制凝血酶原酶复合物中结合的游离因子Xa和因子Xa。 了解更多
  8. Letaxaban (TAK-442)

    Catalog No. A12871
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    factor Xa 抑制剂
    Letaxaban (TAK-442)是一种有效的,选择性的,口服活性的Xa抑制剂,是一种四氢嘧啶-2(1H)-衍生物。TAK-442在贫血小板的人[半最大抑制浓度(IC(50)):53 nM,TAK-442]和大鼠(IC(50):32 nM,TAK-442)血浆中抑制内源性FXa活性。 了解更多
  9. Razaxaban

    Catalog No. A12870
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    factor Xa 抑制剂
    Razaxaban是凝血因子Xa的选择性,有效和口服生物利用抑制剂。 了解更多
  10. Otamixaban (FXV 673)

    Catalog No. A11517
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    factor Xa 抑制剂
    Otamixaban (FXV 673)是一种静脉内直接因子Xa抑制剂。 了解更多
  11. Rivaroxaban (Xarelto)

    Catalog No. A10800
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    Factor Xa 抑制剂
    Rivaroxaban (Xarelto)是一种Factor Xa的直接抑制剂,无细胞试验中Ki和IC50分别为0.4 nM和0.7 nM。 了解更多
  12. BMS-740808

    Catalog No. A10158
    Factor Xa 抑制剂
    BMS-740808是凝血因子Xa的高效,选择性,有效和口服生物利用度抑制剂。 了解更多
  13. Apixaban (BMS-562247-01)

    Catalog No. A10082
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    Factor Xa 抑制剂
    Apixaban (BMS-562247-01)是一种抗凝剂,用于预防静脉血栓栓塞和静脉血栓栓塞事件。 了解更多
  14. Fondaparinux Sodium

    Catalog No. A17918
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    factor Xa inhibitor
    Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). 了解更多
  15. RWJ-445167

    Catalog No. A12154
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    dual inhibitor of thrombin and factor Xa
    RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. 了解更多
  16. Edoxaban

    Catalog No. A18015
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    factor Xa (FXa) inhibitor
    Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. 了解更多
  17. BMS-654457

    Catalog No. A21704
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    Factor XIa (FXIa) inhibitor
    BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively. 了解更多

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