FRAX597

Name: FRAX597
SKU: A12553

目录号: A12553

PAK 抑制剂

Product Citations (1)

FRAX597 Chemical Structure

CAS NO. 1286739-19-2

FRAX597是一种小分子吡啶并嘧啶酮，是I类PAK（PAK1 IC50 = 8 nM，PAK2 IC50 = 13 nM，PAK3 IC50 = 19 nM）的有效和ATP竞争性抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 1,000.00
10 mg	￥ 1,700.00
25 mg	￥ 3,600.00

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生物活性

FRAX597是一种小分子吡啶并嘧啶酮，是I类PAK（PAK1 IC50 = 8 nM，PAK2 IC50 = 13 nM，PAK3 IC50 = 19 nM）的有效和ATP竞争性抑制剂。

靶点信息

PAK1	PAK2	PAK2	PAK3
8 nM	13 nM	13 nM	19 nM

溶解度 *

In vitro	DMSO	Warmed: 13 mg/mL (23.29 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (1.79 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.92 mL	89.59 mL	179.18 mL
0.5 mM	3.58 mL	17.92 mL	35.84 mL
1 mM	1.79 mL	8.96 mL	17.92 mL
5 mM	0.36 mL	1.79 mL	3.58 mL

*The above data is based on the productmolecular weight 558.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12553
作用机制	Inhibitor (抑制剂)
M. Wt	558.1
Formula	C29H28ClN7OS
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1286739-19-2
Synonyms	FRAX 597, FRAX-597
SMILES	CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C