GDC-0068 (Ipatasertib, RG-7440)

目录号: A11246

Akt 抑制剂

GDC-0068 (Ipatasertib, RG-7440)

GDC-0068 (Ipatasertib, RG-7440) Chemical Structure

CAS NO. 1001264-89-6

GDC-0068 (Ipatasertib,RG-7440)是一种选择性的,具有ATP竞争性的pan-Akt抑制剂,在无细胞试验中,其靶向Akt1、2和3的IC50值分别为5、18和8 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 650.00
10 mg
¥ 900.00
25 mg
¥ 1,500.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GDC-0068 (Ipatasertib,RG-7440)是一种选择性的,具有ATP竞争性的pan-Akt抑制剂,在无细胞试验中,其靶向Akt1、2和3的IC50值分别为5、18和8 nM。
靶点信息
Akt1 (Cell-free assay) Akt3 (Cell-free assay) Akt2 (Cell-free assay)
5 nM8 nM18 nM
In vitro DMSO 91 mg/mL (198.69 mM)
Water Insoluble
Ethanol 91 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.83 mL 109.17 mL 218.34 mL
0.5 mM 4.37 mL 21.83 mL 43.67 mL
1 mM 2.18 mL 10.92 mL 21.83 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 458. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11246
作用机制 Inhibitor (抑制剂)
M. Wt 458
Formula C24H32ClN5O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1001264-89-6
Synonyms GDC0068, RG7440
SMILES C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O

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